Evidence map›Paper›PMID 41286197›Full record

SynthesisCurrent environmental health reports2025

Endocrine Disrupting Chemicals in Human Milk: A Systematic Review of Concentrations and Potential Health Implications.

Fiona Dunn, Hannah Sullivan, Megan Romano, Christina D Chambers, Joseph M Braun, Katherine E Manz

Abstract readSystematic ReviewReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current environmental health reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fiona Dunn *MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Hannah Sullivan *Department of Environmental Health Science, University of Michigan, Ann Arbor, MI, 48109, USA.
Megan RomanoDepartment of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, NH, USA.ORCID http://orcid.org/0000-0003-4932-2492
Christina D ChambersDepartment of Pediatrics, University of California San Diego, La Jolla, San Diego, CA, 92093, USA.ORCID http://orcid.org/0000-0003-4675-7722
Joseph M BraunDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.ORCID http://orcid.org/0000-0002-5239-3235
Katherine E ManzDepartment of Environmental Health Science, University of Michigan, Ann Arbor, MI, 48109, USA. katmanz@umich.edu.ORCID http://orcid.org/0000-0002-8225-9168

Funding

Assessment of Early Life PFAS Exposure in Perinatal Biospecimens, Infant Formula, and Breastmilk.K01ES035398 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MANZ, KATHERINE ELIZABETH · 2023 to 2025
$552k
NIEHS NIH HHS K01 ES035398NIEHS NIH HHS K01ES035398
6 · The paper itself

Abstract

purpose of reviewEndocrine-disrupting chemicals (EDCs) disrupt the synthesis, transport, action, or metabolism of endogenous hormones in the human body. EDCs often enter the body through inhalation, ingestion, or dermal contact and can accumulate in the body. Remobilization or transfer of EDCs can occur during lactation, causing human milk to become contaminated with a variety of EDCs, which could expose nursing infants and children to these chemicals. RECENT

findingsSeveral studies have examined the concentration ranges for one or multiple EDC(s) in human milk. Additional studies document associations between EDC exposure and adverse health outcomes, many of which are in adult populations. It is therefore essential to understand the extent to which EDCs in human milk contribute to cumulative early-life exposures. We performed a literature review of peer-reviewed studies reporting concentrations of one or more of the following EDCs in human milk during or after 2004: bisphenols, organochlorine pesticides (OCPs), polycyclic aromatic hydrocarbons (PAHs), parabens, polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFAS), and phthalates. We identified concentration ranges for each chemical detected in human milk and health impacts associated with early-life exposures to EDCs noted across studies from this review. Determining the presence of EDCs in human milk and the associated effects of exposure through nursing is essential to develop feeding recommendations that safeguard infant and child health.

Indexed as

Endocrine DisruptorsEnvironmental PollutantsMilk, HumanBisphenol A CompoundsEnvironmental ExposureFemaleHalogenated Diphenyl EthersHumansHydrocarbons, ChlorinatedInfantParabensPesticidesPhenolsPolycyclic Aromatic HydrocarbonsBisphenol A CompoundsEndocrine DisruptorsEnvironmental PollutantsHalogenated Diphenyl EthersHydrocarbons, ChlorinatedParabensPesticidesPhenolsPolycyclic Aromatic HydrocarbonsEndocrine disrupting chemicalsExposureHuman milkLactationNursing

Identifiers

PMID41286197
PMCPMC12644229

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.