ArticleScientific reports2025
Transcriptome study exploring the mechanisms linking pollutants and breast cancer aggressiveness.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer (BC) is the most common cancer in women, with metastasis as the leading cause of mortality. Persistent organic pollutants (POPs) may increase BC aggressiveness, but mechanisms remain unclear. This study examined the link between POP exposure and BC progression. We analyzed tumor samples from 89 BC patients in the METAPOP cohort, measuring 42 POPs, including dioxins, polychlorinated biphenyls (PCBs), and polybromodiphenylethers (PBDEs). Transcriptomic analysis identified genes differentially expressed in relation to POP exposure and BC aggressiveness (tumor size, metastatic risk, lymph node involvement, and estrogen receptor status). RNA sequencing of 89 tumors identified 4931 genes differentially expressed with ER status, 283 with tumor size, and 99 with metastasis. Key enriched pathways included immune response, extracellular matrix remodeling, and cell cycle regulation. Gene set enrichment analysis revealed significant overlap in pathways regulating the cell cycle, immune response, and BC hallmarks. Findings suggest that POP exposure alters tumor biology, promoting an aggressive phenotype. This study provides novel insights into the role of environmental pollutants in BC progression, emphasizing the need for further research on how POPs contribute to tumor aggressiveness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.