Evidence map›Paper›PMID 41286116›Full record

ArticleNature microbiology2025

Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli.

Santiago E Caño Muñiz, Stephen Trigg, Georgeos Hardo, Anja Hagting, Ieuan E Evans, Christopher Ruis, Ali F Alsulami, David Summers, Felicity Crawshay-Williams, Tom L Blundell and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Fast, StreamlinedChemical & biomedical imaging · 2026
    Article
  3. [Antibacterial activity and mechanism of the antiparasitic drug resorantel againstZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Santiago E Caño MuñizThe Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
Stephen TriggThe Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8031-1516
Georgeos HardoDepartment of Engineering, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0037-1293
Anja HagtingThe Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
Ieuan E EvansUniversity of Cambridge Molecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.
Christopher RuisThe Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0977-5534
Ali F AlsulamiDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
David SummersDepartment of Genetics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8243-9521
Felicity Crawshay-WilliamsThe Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
Tom L BlundellThe Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-2708-8992
Lucas BoeckDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1442-9073
Somenath BakshiDepartment of Engineering, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3864-2546
R Andres FlotoThe Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK. arf27@cam.ac.uk.ORCID http://orcid.org/0000-0002-2188-5659

Funding

Cystic Fibrosis Trust (CF) IH 001Fondation Botnar 6063Wellcome TrustWellcome Trust (Wellcome) 107032AIAWellcome Trust (Wellcome) 226602/Z/22/Z
6 · The paper itself

Abstract

Porins mediate the passage of hydrophilic nutrients and antibiotics across the outer membrane but might contribute to proton leak from the periplasm, suggesting that their conductance could be regulated. Here we show, using single-cell imaging, that porin permeability in Escherichia coli is controlled by changes in periplasmic H

Indexed as

Drug Resistance, BacterialEscherichia coliPorinsAnti-Bacterial AgentsCell Membrane PermeabilityCiprofloxacinEscherichia coli ProteinsHydrogen-Ion ConcentrationPeriplasmPermeabilityPotassiumPotassium ChannelsProtonsReactive Oxygen SpeciesAnti-Bacterial AgentsCiprofloxacinEscherichia coli ProteinsPorinsPotassiumPotassium ChannelsProtonsReactive Oxygen Species

Identifiers

PMID41286116
PMCPMC12669030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.