Evidence map›Paper›PMID 41286084›Full record

Observational studyScientific reports2025

Inflammation and oxidative stress are associated with major adverse cardiovascular events in adults with preclinical hypertension.

Colin J Gimblet, Dariya Kozlova, Linder H Wendt, Sadaf Akbari, Mingyao Sun, Patrick Ten Eyck, Steven Crowley, Diana I Jalal

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Colin J GimbletDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Dariya KozlovaDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Linder H WendtInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA, USA.
Sadaf AkbariDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Mingyao SunDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Patrick Ten EyckInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA, USA.
Steven CrowleyDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC, USA.
Diana I JalalDivision of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA. diana-jalal@uiowa.edu.

Funding

University of Iowa Institute for Clinical and Translational ScienceUM1TR004403 · NCATS · UNIVERSITY OF IOWA · PI Marlan R Hansen, Patricia Winokur · 2023 to 2026
$16.1M
Diabetes Research Training Program Diversity SupplementT32DK112751 · NIDDK · UNIVERSITY OF IOWA · PI Andrew W Norris · 2017 to 2026
$4.8M
National Center For Advancing Translational Sciences of the National Institutes of Health UM1TR004403NCATS NIH HHS UM1 TR004403NIDDK NIH HHS T32 DK112751NIH HHS NIH T32DK112751University of Iowa Department of Medicine Seed fundsVHA Merit HX003533
6 · The paper itself

Abstract

Inflammation and oxidative stress increase with rising blood pressure. Adults with preclinical hypertension (systolic 120-129 mmHg) have a heightened risk of major adverse cardiovascular events (MACE). However, it remains unclear whether inflammation and oxidative stress contribute to MACE risk in this population. We conducted an observational study involving 5405 adults in the Framingham Offspring and Generation III cohorts. Exclusion criteria were anti-hypertensive therapy, history of cardiovascular disease, estimated glomerular filtration rate below 60 ml/min/1.73 m

Indexed as

Cardiovascular DiseasesHypertensionInflammationOxidative StressAdultAgedBiomarkersBlood PressureFemaleHumansMaleMiddle AgedRisk FactorsBiomarkersCardiovascular eventsHypertensionInflammationOxidative stress

Identifiers

PMID41286084
PMCPMC12645037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.