Evidence map›Paper›PMID 41286044›Full record

ArticleScientific reports2025

Identification of potential biomarkers associated with cellular senescence in benign prostatic hyperplasia.

Lei Zhou, Xiao Zhong, Dan Hu, Guoqian Hu, Chao Li, Shuo Tan, Wei Xiong, Lan Li, Jin Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lei Zhou *Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiao Zhong *Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Dan HuDepartment of Urology, The Liuyang Jili Hospital, Changsha, Hunan, China.
Guoqian HuDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chao LiDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shuo TanDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wei XiongDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lan LiDepartment of Urology, The Third Ningxiang People's Hospital, Changsha, Hunan, China.
Jin TangDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. ajin530@139.com.

Funding

China Postdoctoral Science Foundation 2023M743966National Natural Science Foundation of China 82303120Youth Science Foundation of Xiangya Hospital 2023Q19
6 · The paper itself

Abstract

Benign prostatic hyperplasia (BPH) is a prevalent condition among aging men, characterized by prostate enlargement and urinary symptoms. Despite its common occurrence, the molecular mechanisms, particularly those related to cellular senescence, are not well understood. This study aims to pinpoint and analyze cellular senescence-related differentially expressed genes (CSRDEGs) in BPH. We integrated data from GEO datasets GSE119195 and GSE7307, addressing batch effects to ensure data reliability. Differential gene expression analysis revealed key CSRDEGs, which were further analyzed through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, highlighting their involvement in significant biological processes and pathways such as inflammation, cell cycle regulation, and extracellular matrix organization. Protein-protein interaction networks were constructed, and hub genes, including IGF1, SOX2, ID1, WNT2, LGALS3, and KL, were determined and analyzed for their diagnostic potential through receiver operating characteristic curve analysis. Regulatory network analyses of these hub genes exhibited intricate mRNA-miRNA and mRNA-TF interactions, providing insights into post-transcriptional and transcriptional regulation mechanisms. Our findings underscore the crucial role of cellular senescence in BPH pathogenesis and propose novel biomarkers and therapeutic targets. This study enhances our understanding of BPH at the molecular level, offering a foundation for future research aimed at improving diagnosis and treatment.

Indexed as

BiomarkersCellular SenescenceProstatic HyperplasiaComputational BiologyDatabases, GeneticGene Expression ProfilingGene OntologyGene Regulatory NetworksHumansMaleMicroRNAsProtein Interaction MapsRNA, MessengerBiomarkersMicroRNAsRNA, MessengerBenign prostatic hyperplasiaBiomarkersCellular senescenceImmune infiltrationMolecular characterization

Identifiers

PMID41286044
PMCPMC12644519

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.