Evidence map›Paper›PMID 41286034›Full record

ArticleScientific reports2025

Sex difference in the neural correlates of volitional eyes closing.

Yi Zhang, Yuhao Ruan, Panpan Han, Guiyang Lv, Junhan Wang, Jun Gu, Longhui Li, Zemin Xu, Minfang Huang, Jianing Dai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yi ZhangDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, China.
Yuhao RuanSchool of Psychology, Zhejiang Normal University, Jinhua, 321004, China.
Panpan HanDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, China.
Guiyang LvInstitute of Big Data and Artificial Intelligence in Medicine, School of Electronics and Information Engineering, Taizhou University, Taizhou, 318000, China.
Junhan WangSchool of Psychology, Zhejiang Normal University, Jinhua, 321004, China.
Jun GuDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, China.
Longhui LiDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, China.
Zemin XuDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, China.
Minfang HuangDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, China.
Jianing DaiDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, China.
Shuchan WangDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, China.
Xiaohong WuDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, China.
Xinyu LiSchool of Psychology, Zhejiang Normal University, Jinhua, 321004, China. xyli@zjnu.cn.

Funding

Health and Medical Science and Technology Plan Project in Ningbo City No. 2024Y19National Natural Science Foundation of China 62337001Science and Technology Plan Project of Traditional Chinese Medicine in Zhejiang Province 2024ZL158
6 · The paper itself

Abstract

Volitional eyes closing (EC), which shifts brain's information processing modes from the "exteroceptive" to "interoceptive" state, can promote behaviors (such as episodic memory) that exhibit significant sex difference. Although this act is known to reconfigure a large-scale brain network as its neural correlates, sex difference in such network reconfiguration remains unexplored. Here, we compared between genders the EC-effects on functional network, focusing on the intersubject variability in functional connectivity (IVFC), modularity index, local efficiency, and clustering coefficient. While reliable EC-effects were observed in both genders, females demonstrated greater alterations in IVFC and modularity index than males. Moreover, the female-biased effects of EC were supported by a large-scale cortical basis, primarily affecting the default-mode and visual networks. Finally, a positive relationship was discovered between the sex difference of EC-effects and that of brain anatomy. Jointly, our findings suggested that biological sex serves as a potential factor influencing EC's neural correlates, with widespread impacts on cognitive systems and close link to brain anatomy.

Indexed as

BrainNerve NetSex CharacteristicsVolitionAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleYoung AdultDefault-mode and visual networksFunctional brain networkSex differenceVolitional eyes closing

Identifiers

PMID41286034
PMCPMC12644847

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.