Evidence map›Paper›PMID 41285935›Full record

ArticleScientific reports2025

Analysis of the risk of metachronous colorectal cancer and long-term prognosis in patients following gastrectomy for gastric cancer.

Jun He, Bixian Luo, Hongming Liu, Dong Cao, Weihua Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jun He *Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Bixian Luo *Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Hongming Liu *Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Dong CaoDepartment of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Weihua GongDepartment of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, 310058, China. weihuagong@zju.edu.cn.

Funding

Key Research and Development Program of Zhejiang Province 2025C02054
6 · The paper itself

Abstract

The impact of gastrectomy on the risk of developing second colorectal cancer (SCRC) in gastric cancer patients remains unclear. This study aimed to evaluate the association between gastrectomy and SCRC in gastric cancer patients. A total of 17,606 patients with gastric cancer were identified from the SEER database and categorized into gastrectomy (GT) and non-gastrectomy (NGT) groups. Fine-Gray competing risk analysis was employed to calculate the cumulative incidence of SCRC in different groups. Competing risk analysis and Poisson regression were used to assess the association between gastrectomy and SCRC risk. Standardized incidence ratios (SIRs) were calculated to compare CRC incidence in the GT and NGT groups with that in the general US population. A total of 128 patients in the GT group (0.8%) and 9 patients in the NGT group (0.4%) developed SCRC. Gastrectomy was identified as a significant adverse factor in both univariate and multivariate Poisson regression analyses. SIRs revealed a higher CRC incidence in the GT group compared to the general population, while the NGT group showed no significant difference. Gastrectomy is associated with an increased risk of SCRC in gastric cancer patients and significantly improves survival in those who develop SCRC.

Indexed as

Colorectal NeoplasmsGastrectomyNeoplasms, Second PrimaryStomach NeoplasmsAgedFemaleHumansIncidenceMaleMiddle AgedPrognosisRisk FactorsSEER ProgramColorectal cancerGastrectomyGastric cancerStandardized incidence ratioSurvival

Identifiers

PMID41285935
PMCPMC12644800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.