ArticleScientific reports2025
The effects of invasive treatment on patients with frailty and non-ST-segment elevation myocardial infarction.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The effect of invasive treatment in patients with non-ST-segment elevation myocardial infarction (NSTEMI) with associated frailty remains undefined. This retrospective cohort study aimed to compare the outcomes of invasive treatment with conservative management in this specific patient population. We used the Tianjin Health and Medical Big Data Superplatform, with data from 82 hospitals in Tianjin, China, from January 2010 to March 2024. Patients with NSTEMI were included and divided into a non-frailty group (Hospital Frailty Risk Score [HFRS] < 5) and a frailty group (HFRS ≥ 5). Propensity score matching (PSM) was employed to balance the covariates, and invasive treatment was compared with conservative management. The primary endpoint was major adverse cardiac events (MACE), defined as the composite endpoint of all-cause mortality and recurrent myocardial infarction (MI) within 3 years. There were 73,823 NSTEMI patients (median age 66; 32.6% female) included in the analysis: 26,522 patients were in the frailty group, and 47,301 patients were in the non-frailty group. Among NSTEMI patients with frailty, 14,414 patients (54.3%) underwent invasive treatment. Following PSM yielding 6,040 well-matched pairs, frail patients undergoing invasive treatment had a lower risk of recurrent MI (subdistribution hazard ratio [sHR], 0.681; 95% confidence interval [CI] 0.614-0.754; P < 0.001), all-cause mortality (adjusted hazard ratio [aHR], 0.447; 95% CI 0.410-0.488; P < 0.001) and MACE (aHR, 0.516; 95% CI 0.481-0.553; P < 0.001), compared to conservative management. Similar results for invasive treatment compared to conservative management were observed in NSTEMI patients without frailty. Regardless of whether patients had associated frailty or not, invasive treatment was related to a decreased risk of recurrent MI and all-cause mortality in NSTEMI patients, when compared to conservative management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.