Evidence map›Paper›PMID 41285899›Full record

SynthesisNature communications2025

Multi-ancestry investigation of the genomics of erectile dysfunction.

Uri Bright, Yu Chen, Joseph D Deak, Hang Zhou, Daniel F Levey, Joel Gelernter

Abstract readMeta-Analysis
In one paragraph

Synthesis in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Uri BrightDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Yu ChenDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4768-9269
Joseph D DeakDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-0540-6080
Hang ZhouDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7694-6391
Daniel F LeveyDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-8431-9569
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA. joel.gelernter@yale.edu.ORCID http://orcid.org/0000-0002-4067-1859

Funding

7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3M
Genetic Basis of the Risk and Consequences of Cannabis Exposure in HumansR01DA058862 · NIDA · YALE UNIVERSITY · PI DEEPAK Cyril D'SOUZA, JOEL GELERNTER · 2023 to 2026
$2.6M
Using novel data sources across genetic, biological, and social domains to refine genome-wide investigations of substance use disordersK01DA058807 · NIDA · YALE UNIVERSITY · PI Joseph D. Deak · 2024 to 2026
$543k
BLRD VA I01 BX006482BLRD VA IK2 BX005058CSRD VA I01 CX001849NIDA NIH HHS K01 DA058807NIDA NIH HHS R01 DA054869NIDA NIH HHS R01 DA058862U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) K01DA058807U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA054869U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA058862U.S. Department of Veterans Affairs (Department of Veterans Affairs) I01CX001849U.S. Department of Veterans Affairs (Department of Veterans Affairs) IK2BX005058
6 · The paper itself

Abstract

Erectile dysfunction is attributable to numerous biological and psychological issues, and its prevalence increases with age. We conducted genome-wide association studies of erectile dysfunction in AllofUs subjects of European and African ancestry, then meta-analyzed our findings with published datasets [N

Indexed as

Erectile DysfunctionAdultBasic Helix-Loop-Helix ProteinsBlack PeopleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansMaleMiddle AgedPolymorphism, Single NucleotideWhite PeopleBasic Helix-Loop-Helix Proteins

Identifiers

PMID41285899
PMCPMC12749275

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.