Evidence map›Paper›PMID 41285875›Full record

ArticleNature communications2025

pH calibration allows accurate glucose detection in interstitial fluid via reverse iontophoresis.

Wangwang Zhu, Haixia Yu, Wenjun Li, Xi Li, Hao Zheng, Chengcheng Li, Xingguo Zhang, Chenxi Jin, Mutian Wang, Jiaqi Hou and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Wangwang ZhuState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Haixia YuState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.ORCID http://orcid.org/0000-0003-3297-6182
Wenjun LiState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Xi LiState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Hao ZhengState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Chengcheng LiState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Xingguo ZhangState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.ORCID http://orcid.org/0000-0002-8777-2649
Chenxi JinState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Mutian WangState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Jiaqi HouState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Youhao LiuState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Yuxiao MaState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Zhongxu ZhouState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Miao DengState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Peng GuoState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.
Mingzhen LiNHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.
Zhenqiang SongNHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.
Zhihua PuState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China. puzhihua@tju.edu.cn.ORCID http://orcid.org/0000-0002-6309-8186
Dachao LiState Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China. dchli@tju.edu.cn.ORCID http://orcid.org/0000-0002-5010-7047

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82102230
6 · The paper itself

Abstract

Reverse iontophoresis (RI) is a promising non-invasive, wearable technology for the transdermal extraction of interstitial fluid (ISF), which contains rich biomarkers relevant to health status. Despite the advancement of wearable sensors, this technology is still restricted for accurate non-invasive biomarkers detection. The main challenge lies in the instability of ISF extraction during RI. We found that this instability is primarily caused by the skin surface pH variations because of the interaction between the RI-induced H

Indexed as

Extracellular FluidGlucoseIontophoresisAdultBiomarkersCalibrationFemaleHumansHydrogen-Ion ConcentrationMaleSkinWearable Electronic DevicesBiomarkersGlucose

Identifiers

PMID41285875
PMCPMC12644793

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.