Evidence map›Paper›PMID 41285874›Full record

ArticleScientific reports2025

Investigating inflammation of adipose tissue in a diet induced obesity model of OA in female sprague dawley rats.

Nada Abughazaleh, Hannah Smith, Hijab Chaudhri, Ruth-Anne Seerattan, David A Hart, Raylene A Reimer, Walter Herzog

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nada AbughazalehDepartment of Biomedical Engineering, University of Calgary, Calgary, AB, Canada. naabugha@ucalgary.ca.
Hannah SmithDepartment of Biomedical Engineering, University of Calgary, Calgary, AB, Canada.
Hijab ChaudhriDepartment of Biological Sciences, University of Calgary, Calgary, AB, Canada.
Ruth-Anne SeerattanFaculty of Kinesiology, University of Calgary, Calgary, AB, Canada.
David A HartMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
Raylene A ReimerFaculty of Kinesiology, University of Calgary, Calgary, AB, Canada.
Walter HerzogDepartment of Biomedical Engineering, University of Calgary, Calgary, AB, Canada.

Funding

The Arthritis Society SOG-10-052The Canada Research Chair Program 950-200955,The Canadian Institutes of Health Research FDN-143341The McCaig Institute for Bone and Joint Health 10010760
6 · The paper itself

Abstract

This study was aimed at evaluating the disturbance of mesenteric fat, and the infrapatellar fat pad (IFP) of the knee, and their potential contribution to systemic inflammation and local inflammation in the knee, and the development of knee joint OA in female Sprague-Dawley rats.Female rats were randomized into two groups; a Chow-fed group (Chow) and rats fed a high-fat and high-sucrose diet (HFS). Body composition, serum lipid profile, insulin resistance, serum and synovial fluid inflammatory markers, knee joint degeneration, and adipocyte size in the two fat depots were assessed after 12 weeks of the diet interventions. Mesenteric fat macrophage infiltration and infrapatellar fat pad fibrosis were also quantified.Rats from the HFS group had higher body fat, serum triglycerides levels, serum cholesterol levels, insulin resistance, increases in selected serum biomarkers such as TNF-α, leptin, MCP-1, and MIP-1α, and more severe cartilage degeneration and subchondral bone lesions than did the Chow-fed control rats. However, no increase in macrophage infiltration and fibrosis in the fat tissues were observed in the HFS group compared to the chow-fed group.The mesenteric fat and IFP were protected from inflammation associated with the HFS diet in the female rats, indicating a sex-based difference in the response to the HFS diet. However, cartilage degeneration and subchondral bone lesions were increased in the HFS compared to the control group rats, suggesting that the mechanisms resulting in knee OA development and progression in female rats may distinctly differ from that of male rats.

Indexed as

Adipose TissueDiet, High-FatInflammationObesityOsteoarthritisOsteoarthritis, KneeAnimalsBiomarkersDisease Models, AnimalFemaleInsulin ResistanceMacrophagesRatsRats, Sprague-DawleyBiomarkersDiet-induced obesityFemale sprague–dawley ratsInfrapatellar fat padMesenteric fatOsteoarthritisSex differences

Identifiers

PMID41285874
PMCPMC12644849

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.