Evidence map›Paper›PMID 41285837›Full record

ArticleNPJ systems biology and applications2025

NF-κB epigenetic attractor landscape drives breast cancer heterogeneity.

Francisco Lopes, Bruno R B Pires, Alexandre A B Lima, Renata Binato, Eliana Abdelhay

Abstract read
In one paragraph

Article in NPJ systems biology and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francisco LopesUniversidade Federal do Rio de Janeiro, Campus Duque de Caxias Professor Geraldo Cidade, Duque de Caxias, Brazil. flopes@ufrj.br.
Bruno R B PiresDepartamento de Biofísica e Biometria (DBB), Universidade Estadual do Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
Alexandre A B LimaUniversidade Federal do Rio de Janeiro, Campus Duque de Caxias Professor Geraldo Cidade, Duque de Caxias, Brazil.
Renata BinatoStem Cell Laboratory, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
Eliana AbdelhayStem Cell Laboratory, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 200176/2022-6
6 · The paper itself

Abstract

Heterogeneity in breast cancer (BC) subtypes within a tumor contributes to therapy resistance and cancer recurrence. Subtype heterogeneity in tumors arises through a combination of stochastic genetic/epigenetic changes, phenotypic plasticity, and microenvironment-driven selection as the tumor evolves over time. Here, we sought to characterize how NF-κB epigenetic variability contributes to the progression of the HER2

Indexed as

Breast NeoplasmsEpigenesis, GeneticNF-kappa BCell Line, TumorFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksGenetic HeterogeneityHumansTriple Negative Breast NeoplasmsNF-kappa B

Identifiers

PMID41285837
PMCPMC12644762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.