ArticleNature communications2025
A shared central thalamus mechanism underlying diverse recoveries in disorders of consciousness.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The Efficacy of Individualized Music Therapy in Patients With MCS: A Pilot Study on EEG.Neural plasticity · 2026Trial
- Recovery from disorders of consciousness: Lesions and GABAergic modulation in a biologically inspired spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dynamic Global and Local Enhancement of Theta-Band Functional Networks as Neural Markers of Spinal Cord Stimulation Efficacy in Disorders of Consciousness.CNS neuroscience & therapeutics · 2026Article
- Deep Brain Stimulation for Disorders of Consciousness: From Mesocircuit Mechanisms to Circuit-Guided Precision Neuromodulation.Neuroscience bulletin · 2026Review
- Advances in local field potential research in prolonged disorders of consciousness: a narrative review.Chinese neurosurgical journal · 2026Review
- Temporal Interference Stimulation of Centromedian-Parafascicular Complex in Disorders of Consciousness: A Pilot Study.Annals of clinical and translational neurology · 2026Article
- Advances in biomarkers for diagnosing and prognosticating disorders of consciousness.Frontiers in neuroscience · 2026Review
- Neuromodulation for pediatric disorders of consciousness: bridging the gap between adult evidence and developmental reality.Frontiers in neurologyReview
- Theta-band EEG functional connectivity during emotional music in disorders of consciousness: wPLI differences between MCS and UWS.Frontiers in neurologyArticle
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Authors and funding
10 authors.
Funding
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Abstract
Disorders of consciousness (DoC) encompass a range of states characterized by prolonged altered awareness due to heterogeneous brain damage and are associated with highly diverse prognoses. However, the neural mechanisms underlying such diverse recoveries in DoC remain unclear. To address this issue, we analyzed direct recordings from the central thalamus (CeTh), a key hub in arousal regulation, in a series of 23 DoC patients receiving deep brain stimulation treatment (CeTh-DBS). We identified a core set of electrophysiological features of the CeTh, particularly those of the theta rhythm. These features could account for individual recovery outcomes across highly varied etiologies (trauma, brainstem hemorrhage, and anoxia), and across clinical baselines and patient ages. CeTh activities also identified two subgroups of patients with recovery potential, including those with poor initial clinical manifestations but who eventually exhibited functional recovery. A biophysical model further revealed the neurodynamics of the theta rhythm in the CeTh across different brain states correlating with varying consciousness levels. These findings uncover a shared CeTh mechanism underlying diverse recoveries in DoC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.