Evidence map›Paper›PMID 41285793›Full record

ArticleNature communications2025

Identification of inducible HIV reservoirs in tonsillar, intestinal and cervical tissue models of HIV latency.

A Gallego-Cortés, N Sánchez-Gaona, C Mancebo-Pérez, O Ruiz-Isant, A Benítez-Martínez, S Landolfi, J Castellví, F Pumarola, N Ortiz, I Llano and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Resident CD49aScience advances · 2026
    Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

A Gallego-CortésInfectious Diseases Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID https://orcid.org/0000-0001-5126-600X
N Sánchez-GaonaInfectious Diseases Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID https://orcid.org/0000-0003-1977-8691
C Mancebo-PérezInfectious Diseases Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-5960-5168
O Ruiz-IsantInfectious Diseases Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID https://orcid.org/0009-0005-6582-2675
A Benítez-MartínezInfectious Diseases Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID https://orcid.org/0009-0003-7252-3564
S LandolfiDepartment of Pathology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.ORCID https://orcid.org/0000-0002-1059-635X
J CastellvíDepartment of Pathology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.ORCID http://orcid.org/0000-0001-5745-9996
F PumarolaDepartment of Otorhinolaryngology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7914-1695
N OrtizDepartment of Otorhinolaryngology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.ORCID http://orcid.org/0009-0009-2939-7201
I LlanoDepartment of Otorhinolaryngology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
J LorenteDepartment of Otorhinolaryngology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.ORCID https://orcid.org/0000-0002-3264-0251
L Mañalich-BarrachinaDepartment of Obstetrics and Gynecology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.ORCID http://orcid.org/0000-0002-4624-4671
J G PradoIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.ORCID http://orcid.org/0000-0002-5439-4645
E Martín-GayoCentro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.ORCID http://orcid.org/0000-0002-2619-6086
V FalcóInfectious Diseases Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-9626-0023
M GenescàInfectious Diseases Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-6413-3812
M J BuzonInfectious Diseases Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain. mariajose.buzon@vhir.org.ORCID http://orcid.org/0000-0003-4427-9413

Funding

"la Caixa" Foundation (Caixa Foundation) LCF/PR/HR20/00218Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) CPII22/00005Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI20/00160
6 · The paper itself

Abstract

HIV persists in diverse tissues, with distinct cellular reservoirs presenting a major barrier to a cure and requiring targeted therapeutic strategies to address this heterogeneity. Here, we develop tissue models of HIV latency using human tonsillar, intestinal and cervicovaginal tissues. These models reveal differential HIV infection across CD4

Indexed as

Cervix UteriHIV-1HIV InfectionsIntestinesPalatine TonsilVirus LatencyAntigens, CDCD4-Positive T-LymphocytesDisease ReservoirsFemaleHumansIntestinal MucosaAntigens, CD

Identifiers

PMID41285793
PMCPMC12645015

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.