ArticleNPJ Parkinson's disease2025
Daily steps are a predictor of, but perhaps not a risk factor for Parkinson's disease: findings from the UK Biobank.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Real-world gait changes preceding Parkinson's disease diagnosis in a population-scale UK biobank cohort.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- UK Biobank at 20 - a growing, global resource for dementia research.Nature reviews. Neurology · 2026Review
- Continuous assessment of daily-living gait using self-supervised learning of wrist-worn accelerometer data.NPJ digital medicine · 2026Article
Corrections and comments
- Update of
Authors and funding
11 authors.
Funding
Abstract
Previous studies link lower physical activity with incident Parkinson's disease (PD) but rely on self-reported data and fail to address reverse causation. This study used accelerometer-derived daily step count, an objective measure of physical activity, to examine its association with incident PD in the UK Biobank, within successive periods of follow-up. PD cases were identified through hospital inpatient and death data, and associated with machine learning-derived step counts using Cox regression models, adjusted for age, sex, demographic and lifestyle factors. For 94,696 valid participants and a median follow-up of 7.9 years, 407 incident PD cases occurred. Every 1000 steps higher were associated with 8% lower risk of PD (hazard ratio 0.92, 95% confidence interval 0.89-0.94). However, this association was no longer statistically significant when excluding follow-up periods closer to the time of accelerometer wear, suggesting that low activity may be an early marker, but not a risk factor for PD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.