Evidence map›Paper›PMID 41285614›Full record

ArticleRNA (New York, N.Y.)2026

Loop of fate: structural and mechanistic insights into hnRNPA1 binding to the hepatitis C virus RNA.

Ajit Kumar, Srinivasa Penumutchu, Love Panchariya, Priyanka Kumari, Shubham Thakur, Purba Daripa, Vandana Singh, Arockiasamy Arulandu, Souvik Maiti, Mandar V Deshmukh and 1 more

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ajit KumarCSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India.ORCID 0000-0003-3940-6270
Srinivasa PenumutchuDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Love PanchariyaStructural Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi 110067, India.ORCID 0000-0002-2194-1323
Priyanka KumariCSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India.
Shubham ThakurCSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India.
Purba DaripaCSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India.
Vandana SinghCSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India.
Arockiasamy ArulanduStructural Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi 110067, India.ORCID 0000-0002-4606-8006
Souvik MaitiCSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India.ORCID 0000-0001-9897-1419
Mandar V DeshmukhCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, Telangana, India.ORCID 0000-0003-2447-9725
Niyati JainCSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India niyati2002us@gmail.com.ORCID 0000-0002-1524-2411

Funding

TRD3 NMRbox: Bayesian AnalyticsP41GM111135 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOCH, JEFFREY C · 2015 to 2024
$14.0M
NIGMS NIH HHS P41 GM111135
6 · The paper itself

Abstract

Hepatitis C virus (HCV) is a major global health burden, associated with chronic liver diseases, including cirrhosis and hepatocellular carcinoma. Viral replication critically depends on conserved

Indexed as

HepacivirusHeterogeneous Nuclear Ribonucleoprotein A1RNA, ViralBinding SitesHumansNucleic Acid ConformationProtein BindingVirus ReplicationHeterogeneous Nuclear Ribonucleoprotein A1hnRNPA1 protein, humanRNA, Viral5BSL3.2 stem–loopcis-acting replication element (CRE)hepatitis C virus (HCV)hnRNPA1RNA–protein interaction

Identifiers

PMID41285614
PMCPMC12810188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.