Evidence map›Paper›PMID 41285570›Full record

Observational studyVox sanguinis2026

Multinational transfusion practices and outcomes in haematology patients admitted to the intensive care unit.

Caroline M Schaap, Laurens A Oomen, Senta Jorinde Raasveld, Jimmy Schenk, Sanne de Bruin, Merijn C Reuland, Claudia van den Oord, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser and 34 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Caroline M SchaapDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Laurens A OomenDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID https://orcid.org/0009-0001-3634-5129
Senta Jorinde RaasveldDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Jimmy SchenkDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Sanne de BruinDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Merijn C ReulandDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID https://orcid.org/0009-0009-3738-0397
Claudia van den OordDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Jan BakkerDepartment of Intensive Care Adults, Erasmus MC University Medical Centers, Rotterdam, The Netherlands.
Maurizio CecconiDepartment of Anesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy.
Aarne FeldheiserDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, EvangKliniken Essen-Mitte, Huyssens-Stiftung/Knappschaft, Essen, Germany.
Jens MeierDepartment of Anesthesiology and Intensive Care, Kepler University Clinic, Linz, Austria.
Zoe McQuiltenSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Thomas W L ScheerenDepartment of Anesthesiology, University Medical Center Groningen, Groningen, The Netherlands.
Cécile AubronMédecine Intensive Réanimation, CHU de Brest, Université de Bretagne Occidentale, Brest, France.ORCID https://orcid.org/0000-0002-7808-3606
Andrew W J FlintSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Tarikul HamidDepartment of Critical Care, Asgar Ali Hospital, Dhaka, Bangladesh.
Michaël PiagnerelliDepartment of Intensive Care, CHU Charleroi Marie Curie, Université Libre de Brussels, Charleroi, Belgium.
Tina Tomić MahečićDepartment of Anesthesiology and Intensive Care, University Clinical Hospital Center Zagreb, Zagreb, Croatia.
Jan BenesDepartment of Anesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine in Plzen-Charles University, Plzen, Czech Republic.
Lene RussellDepartment of Intensive Care, Copenhagen University Hospital, Rigshospitalet Copenhagen, Copenhagen, Denmark.
Hernan Aguirre-BermeoIntensive Care Unit, Hospital General Monte Sinaí, Cuenca, Ecuador.
Konstantina TriantafyllopoulouDepartment of Cardiothoracic Surgery, European Interbalkan Medical Center, Thessaloniki, Greece.
Vasiliki ChantziaraIntensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Chest Hospital, Athens, Greece.
Mohan GurjarDepartment of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.ORCID https://orcid.org/0000-0002-8489-0324
Sheila Nainan MyatraDepartment of Anesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Vincenzo PotaDepartment of Child, General and Specialistic Surgery, University of Campania, Luigi Vanvitelli, Naples, Italy.ORCID https://orcid.org/0000-0001-9999-3388
Muhammed ElhadiFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Ryszard GawdaDepartment of Anesthesiology and Intensive Care, Institute of Medical Sciences, University of Opole, Opole, Poland.
Mafalda MouriscoDepartment of Intensive Care, Centro Hospitalar de Entro o Douro e Vouga, Santa Maria da Feira, Portugal.
Marcus LanceDepartment of Anesthesiology, Aga Khan University Hospital, Nairobi, Kenya.ORCID https://orcid.org/0000-0002-7484-5132
Vojislava NeskovicClinic for Anesthesiology and Critical Care, Military Medical Academy, Belgrade, Serbia.
Matej PodbregarDepartment for Internal Intensive Care, General Hospital Celje, Medical Faculty, University of Ljubljana, Celje, Slovenia.
Juan V LlauDepartment of Anesthesiology and Post-surgical Critical Care, University Hospital Doctor Peset, Valencia, Spain.
Manual Quintana-DiazIntensive Care Service, Hospital Universitario La Paz, Madrid, Spain.
Maria CronhjortDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Carmen A PfortmuellerDepartment of Intensive Care, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Nihan YapiciDepartment of Anesthesiology and Reanimation, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, University of Health Sciences, Istanbul, Turkey.
Nathan NielsenDivision of Pulmonary, Critical Care and Sleep Medicine, and Section of Transfusion Medicine and Therapeutic Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Harm-Jan de GroothDepartment of Intensive Care, Utrecht University Medical Centers, Utrecht, The Netherlands.
Alexander P J VlaarDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Bart J BiemondDepartment of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Akshay ShahNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Marcella C A MüllerDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
InPUT Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe number of critically ill patients with haematological conditions is increasing, yet transfusion practices in this population remain poorly defined. This study aimed to compare transfusion strategies in critically ill patients with versus without haematological conditions. STUDY DESIGN AND

methodsThis international, prospective observational substudy of the International Point Prevalence Study of Intensive Care Unit [ICU] Transfusion Practices (InPUT) evaluated transfusion use in ICU patients with and without haematological conditions, including benign or malignant diseases or a history of stem cell transplantation. Outcomes included use of red blood cells (RBCs), platelets, plasma, haemostatic interventions, transfusion indications and thresholds.

resultsOf 3643 ICU patients, 131 (3.6%) had a haematological condition. These patients were more likely to receive RBC (odds ratio [OR] 1.58, 95% confidence interval [CI] 1.09-2.29) and platelet transfusions (OR 8.32, 95% CI 5.09-13.6), primarily due to low haemoglobin rather than physiological triggers. Platelet thresholds were lower (median 23 × 10

conclusionICU patients with haematological conditions receive transfusions differently, particularly regarding platelet and plasma use. These findings underscore the need for prospective studies to define optimal transfusion thresholds in this growing and vulnerable patient population, although the study's limited sample size and lack of diagnostic granularity may affect interpretation.

Indexed as

Blood TransfusionHematologic DiseasesIntensive Care UnitsAgedCritical IllnessFemaleHumansMaleMiddle AgedPlatelet TransfusionProspective Studiescritically illhaematological patientsintensive care unitplateletred blood celltransfusion practices

Identifiers

PMID41285570
PMCPMC12890436

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.