ArticleJournal of epidemiology2026
Validation of Recorded Diagnoses of Acute Kidney Injury Among Surgical Patients in the Japanese Diagnosis Procedure Combination Database.
Article in Journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundResearchers widely use the Diagnosis Procedure Combination (DPC) database for studies on acute-care hospitalization in Japan. However, the validity of acute kidney injury (AKI) diagnostic codes among patients who underwent surgery under general anesthesia is unclear.
methodsUnder the Japanese Next-Generation Healthcare Infrastructure Act, we obtained DPC data linked with the laboratory data of adult surgical patients with baseline and follow-up serum creatinine measurements from three hospitals (2021-2024). Recorded diagnoses of AKI were identified using the International Classification of Diseases-10
resultsAmong 7,374 eligible patients, 663 (9.0%) met the KDIGO-defined AKI criteria, while 35 (0.5%) patients had the AKI codes. The sensitivity was 4.1% (95% CI, 2.7-5.9%), and the specificity was 99.9% (95% CI, 99.8-99.9%). The sensitivity increased for patients with stages 2 and 3 AKI, lower eGFR, emergent admission, or cardiovascular surgery.
conclusionAmong surgical patients, AKI coding in the DPC exhibited high specificity and positive predictive value, albeit low sensitivity. Incorporating laboratory data is important for more accurate identification of patients with AKI for use in clinical studies.
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