Evidence map›Paper›PMID 41285456›Full record

ArticleThe Journal of veterinary medical science2026

Roles of non-structural protein 1 in dengue virus replication and immunomodulation in vivo.

Kazi Anowar Hossain, Bouchra Kitab, Risa Kono, Kenki Momohara, Rupaly Akhter, Md Haroon Or Rashid, Ahmed M Soliman, Tatsuro Hifumi, Mya Myat Ngwe Ngwe Tun, Mohammad Enamul Hoque Kayesh and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kazi Anowar HossainTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Bouchra KitabTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Risa KonoDepartment of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kenki MomoharaTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Rupaly AkhterTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Md Haroon Or RashidTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Ahmed M SolimanTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Tatsuro HifumiDepartment of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Mya Myat Ngwe Ngwe TunDepartment of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Mohammad Enamul Hoque KayeshTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Kouichi MoritaDepartment of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Michinori KoharaDepartment of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kyoko Tsukiyama-KoharaTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DENV) is a vector-borne positive-sense RNA virus causing the dengue epidemic in tropical and subtropical regions. Non-structural viral protein 1 (NS1) is a key modulator of host-pathogen interactions. We investigated the in vivo effect of NS1 on DENV infection using an NS1-expressing recombinant vaccinia virus DIs strain (rDIs-DENV2C-NS1). NS1 expression and anti-NS1 antibody induction were observed. To assess its functional role, rDIs-DENV2C-NS1 was administered to AG129 mice lacking type I and II interferon receptors. Two weeks post-immunization, the mice were challenged with DENV2C (10

Indexed as

DengueDengue VirusImmunomodulationViral Nonstructural ProteinsVirus ReplicationAnimalsAntibodies, ViralCytokinesFemaleMiceViral LoadAntibodies, ViralCytokinesViral Nonstructural Proteinsdengue virusimmune responsein vivonon-structural protein 1 (NS1)viral replication

Identifiers

PMID41285456
PMCPMC12950299

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.