Evidence map›Paper›PMID 41284954›Full record

ArticleNeurology2025

Early Post-Thrombectomy MRI Markers: Temporal Evolution and Association With Reperfusion and Clinical Outcome.

Marie L Luby, Amie W Hsia, Sana Somani, Carolyn A Lomahan, Yongwoo Kim, Shannon P Burton, Veronica Craft, Leila C Thomas, Victoria Uche, Anushree Dhawan and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marie L LubyStroke Branch, NIH, Bethesda, MD.ORCID 0000-0001-7698-5123
Amie W HsiaStroke Branch, NIH, Bethesda, MD.ORCID 0000-0002-0214-9736
Sana SomaniStroke Branch, NIH, Bethesda, MD.
Carolyn A LomahanStroke Branch, NIH, Bethesda, MD.
Yongwoo KimStroke Branch, NIH, Bethesda, MD.
Shannon P BurtonStroke Branch, NIH, Bethesda, MD.
Veronica CraftStroke Branch, NIH, Bethesda, MD.
Leila C ThomasStroke Branch, NIH, Bethesda, MD.
Victoria UcheStroke Branch, NIH, Bethesda, MD.
Anushree DhawanStroke Branch, NIH, Bethesda, MD.
Meghan HildrethStroke Branch, NIH, Bethesda, MD.
Maureen PajunarStroke Branch, NIH, Bethesda, MD.
Bailey SowersStroke Branch, NIH, Bethesda, MD.
Rainier CabatbatStroke Branch, NIH, Bethesda, MD.
Michael KlineStroke Branch, NIH, Bethesda, MD.
Jill B De VisStroke Branch, NIH, Bethesda, MD.
José G MerinoComprehensive Stroke Center, MedStar Washington Hospital Center, Washington, DC.ORCID 0000-0002-6676-0008
Clinton B WrightStroke Branch, NIH, Bethesda, MD.ORCID 0000-0002-9797-6215
John K LynchStroke Branch, NIH, Bethesda, MD.ORCID 0000-0003-2149-4276
Rebecca F GottesmanStroke Branch, NIH, Bethesda, MD.ORCID 0000-0002-9504-1256
Lawrence L LatourStroke Branch, NIH, Bethesda, MD.ORCID 0000-0001-6160-5263

Funding

CLINICAL, IMAGING, AND EXPERIMENTAL CORE SUPPORT OF ACUTE STROKE RESEARCHZIANS003044 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LATOUR, LAWRENCE · 2009 to 2014
$24.9M
Intramural NIH HHS ZIA NS003044
6 · The paper itself

Abstract

BACKGROUND AND

objectivesA significant proportion of patients with ischemic stroke treated with endovascular therapy (EVT) do not achieve favorable clinical outcomes despite successful recanalization. Identifying patients who may benefit from adjunctive therapies is a priority. We hypothesized that incomplete reperfusion is associated with evolution of imaging markers on early post-EVT MRI and clinical outcome.

methodsPatients who underwent attempted EVT for anterior circulation large vessel occlusion (LVO) stroke and had early (<6 hours) and planned 24-hour MRI were enrolled in the Guiding neUroprotection After Reperfusion to prevent Damage in acute ischemic Stroke study. Imaging markers were evaluated by consensus, blinded to clinical data except for the LVO target. Frequencies of imaging markers and lesion patterns, and their associations with reperfusion and clinical outcome were reported. Good clinical outcome was defined as modified Rankin Scale (mRS) score 0-2 at 30 days.

resultsA total of 207 patients were included: median age 67 years, 53% female, 47% Black or African American, admission NIH Stroke Scale (NIHSS) score 16 (10-21), preadmission mRS score 0 (0-1), and onset-to-triage time 192 minutes. Patients with incomplete reperfusion (54%) had higher apparent diffusion coefficient (ADC) and perfusion volumes after EVT and, by 24 hours, exhibited higher rates of lesion growth and edema. Thirty-five percent of those with early incomplete reperfusion had a mixed perfusion pattern at 24 hours. A stable lesion pattern was seen in only 12% of all patients at 24 hours. Early complete reperfusion was associated with lower NIHSS scores (8 vs 13, DISCUSSION: This observational study systematically characterized MRI markers at serial follow-up early after EVT. The heterogeneous and dynamic evolution observed during the hours and days after EVT in most patients suggests further opportunity to intervene, with early incomplete reperfusion and reperfusion injury as prognostic differentiators. Our findings can serve as a roadmap for designing future clinical trials to develop adjunctive therapies targeting these imaging markers.

Indexed as

Ischemic StrokeMagnetic Resonance ImagingReperfusionThrombectomyAgedAged, 80 and overEndovascular ProceduresFemaleHumansMaleMiddle AgedTime FactorsTreatment Outcome

Identifiers

PMID41284954
PMCPMC12684243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.