Evidence map›Paper›PMID 41284881›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Inhibition of fusidic acid resistance through restricting conformational flexibility in domain III of EF-G.

Alexandra Schindl, Megan E Jones, Leela Ghimire, Arnout P Kalverda, Gemma Wildsmith, Antonio N Calabrese, Jennifer H Tomlinson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Inhibition of fusidic acid resistance through restricting conformational flexibility in domain III of EF-G.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandra SchindlSchool of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Megan E JonesSchool of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID 0009-0001-4325-3505
Leela GhimireNewcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.ORCID 0009-0006-7026-6308
Arnout P KalverdaSchool of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Gemma WildsmithSchool of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Antonio N CalabreseSchool of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID 0000-0003-2437-7761
Jennifer H TomlinsonSchool of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID 0000-0003-4081-5055

Funding

TRD3 NMRbox: Bayesian AnalyticsP41GM111135 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOCH, JEFFREY C · 2015 to 2024
$14.0M
NIGMS NIH HHS P41 GM111135Royal Society (The Royal Society) DH160089UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V000837/1Wellcome Trust FC001029Wellcome Trust (WT) 220628/Z/20/Z
6 · The paper itself

Abstract

Fusidic acid (FA) is one of few remaining antibiotics active against Methicillin-resistant

Indexed as

Anti-Bacterial AgentsBacterial ProteinsDrug Resistance, BacterialFusidic AcidPeptide Elongation Factor GMethicillin-Resistant Staphylococcus aureusProtein ConformationProtein DomainsRibosomesAnti-Bacterial AgentsBacterial ProteinsFusidic AcidPeptide Elongation Factor Gantimicrobial resistanceconformational flexibilityElongation Factor-GFusBNMR

Identifiers

PMID41284881
PMCPMC12685103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.