Evidence map›Paper›PMID 41284863›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Genetic testing predicts appearance but not behavior in dogs.

Kathryn A Lord, Vista Sohrab, Kasia Bryc, Michelle E White, Brittney Kenney, Kathleen Morrill Pirovich, Frances L Chen, Elinor K Karlsson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Genetic testing predicts appearance but not behavior in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Genomic ancestry, behavior, and the domestication of the dog.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kathryn A LordGenomics and Computational Biology, UMass Chan Medical School, Worcester, MA 01655.ORCID 0000-0003-0676-8945
Vista SohrabGenomics and Computational Biology, UMass Chan Medical School, Worcester, MA 01655.ORCID 0000-0001-7877-2615
Kasia BrycMedical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142.ORCID 0009-0006-7659-1056
Michelle E WhiteMedical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Brittney KenneyGenomics and Computational Biology, UMass Chan Medical School, Worcester, MA 01655.
Kathleen Morrill PirovichGenomics and Computational Biology, UMass Chan Medical School, Worcester, MA 01655.ORCID 0000-0002-9139-453X
Frances L ChenGenomics and Computational Biology, UMass Chan Medical School, Worcester, MA 01655.ORCID 0000-0001-6441-9677
Elinor K KarlssonGenomics and Computational Biology, UMass Chan Medical School, Worcester, MA 01655.ORCID 0000-0002-4343-3776

Funding

Transforming family dogs into a powerful and accessible model for human cancerR37CA218570 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KARLSSON, ELINOR · 2018 to 2022
$3.2M
Leveraging canine spontaneous cancer to optimize the power of blood biopsyR01CA255319 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KARLSSON, ELINOR, LONDON, CHERYL A · 2021 to 2025
$3.1M
Collaborative Research: EDGE CMT: Utilizing adaptive variation in predatory behavior to uncover the relationship between genes and complex behavioral phenotypesR56HG013639 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KARLSSON, ELINOR · 2024 to 2024
$771k
NCI NIH HHS R01 CA255319NCI NIH HHS R37 CA218570NHGRI NIH HHS R56 HG013639
6 · The paper itself

Abstract

Genetic tests for behavioral and personality traits in dogs are now being marketed to pet owners, but their predictive accuracy has not been validated. To evaluate the reliability of such tests, we analyzed data from Darwin's Ark, a community science initiative that includes over 3,000 dogs with both genetic data and individual-level behavioral phenotypes. None of the candidate variants had significant associations or predictive power for behavioral traits as previously reported. However, we found strong associations with aesthetic traits that differentiate breeds, such as height, leg length, and ear shape. Our results suggest that earlier studies using breed-average phenotypes, rather than individually measured phenotypes, were confounded by population structure. Behavior in dogs is polygenic and complex, and thus cannot be accurately predicted using tests that consider only a few genetic variants. Furthermore, behavior in dogs is only moderately heritable, and environmental influences inherently limit the potential accuracy of genomic predictions. Developing meaningful, accurate genetic predictions for complex traits that can improve dog health and welfare will require very large cohorts of individually phenotyped dogs.

Indexed as

Behavior, AnimalGenetic TestingAnimalsDogsFemaleMalePhenotypeartificial selectionbehaviordoggenetic testinggenomic prediction

Identifiers

PMID41284863
PMCPMC12684939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.