Evidence map›Paper›PMID 41284862›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning.

Qingyi Jia, Jinhang Zhang, Haiying Song, Jiahao Chen, Zhenyu Zhang, Huihui Yu, Yi Chen, Qinhui Liu, Xiandan Jing, Haixia Xu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Qingyi JiaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.ORCID 0000-0002-8586-7046
Jinhang ZhangDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Haiying SongDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Jiahao ChenDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Zhenyu ZhangDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Huihui YuDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.ORCID 0009-0002-9178-229X
Yi ChenDepartment of General Surgery, Division of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Qinhui LiuDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Xiandan JingDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Haixia XuDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Jingwei LiDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Yimin XiongDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Meilin MaDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Na YangDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Junyan LiDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Yining XuDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.ORCID 0000-0001-6201-9338
Yanping LiDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Jinhan HeDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.ORCID 0000-0001-6487-4696

Funding

1.3.5 Project for Disciplines of Excellence ZYGD24006innovation group project from Science & Technology Department of Sichuan Province 2023NSFSC1993MOST | National Natural Science Foundation of China (NSFC) 82025007MOST | National Natural Science Foundation of China (NSFC) 82300941MOST | National Natural Science Foundation of China (NSFC) 82370869MOST | National Natural Science Foundation of China (NSFC) U24A20676National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University Z2024YY003Sichuan Natural Science Foundation 2024NSFSC1614
6 · The paper itself

Abstract

The browning of white adipose tissue (WAT) enhances thermogenesis and holds great potential in obesity treatment. Membrane receptors have been proven as essential factors during WAT browning. In this study, we found that transmembrane receptor neuroplastin-55 (Np55) was markedly upregulated in the adipose tissue of both obese individuals and mice. Fat-specific Np55 knockout (Np55

Indexed as

Adipose Tissue, BrownAdipose Tissue, WhiteMembrane GlycoproteinsNerve Growth FactorsAnimalsDiet, High-FatDisease Models, AnimalEnergy MetabolismHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutObesityPolymorphism, Single NucleotideMANF protein, humanMANF protein, mouseMembrane GlycoproteinsNerve Growth Factorsneuroplastin protein, mouseNPTN protein, humanadipose tissue browningmembrane receptorNp55obesity

Identifiers

PMID41284862
PMCPMC12685124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.