Evidence map›Paper›PMID 41284858›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

From nematode to Nobel: How community-shared resources fueled the rise of

Victor R Ambros, Martin Chalfie, Aric L Daul, Andrew Z Fire, David H Hall, H Robert Horvitz, Craig C Mello, Gary Ruvkun, Nathan E Schroeder, Paul W Sternberg and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Victor R AmbrosProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0000-0002-5562-5345
Martin ChalfieDepartment of Biological Sciences, Columbia University, New York, NY 10027.ORCID 0000-0002-9079-7046
Aric L DaulDepartment of Genetics, Cell Biology and Development, Caenorhabditis Genetics Center, University of Minnesota, Minneapolis, MN 55455.
Andrew Z FireDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-6217-8312
David H HallDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
H Robert HorvitzHHMI, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-9964-9613
Craig C MelloRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Gary RuvkunDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0002-7473-8484
Nathan E SchroederDepartment of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0003-3327-2136
Paul W SternbergDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-7699-0173
Ann E RougvieDepartment of Genetics, Cell Biology and Development, Caenorhabditis Genetics Center, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-8743-6143

Funding

Text mining in the CloudU24HG010859 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CAROL J BULT, PAUL Warren STERNBERG · 2019 to 2026
$42.0M
WormBase: a core data resource for C. elegans and other nematodesU24HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIM SCHEDL, PAUL Warren STERNBERG · 2018 to 2026
$18.9M
GENETIC AND MOLECULAR BASIS OF LONGEVITYR01AG016636 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GARY B RUVKUN · 1999 to 2026
$12.4M
Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Julie Secombe · 2021 to 2026
$7.0M
HHS | NIH | National Human Genome Research Institute (NHGRI) U24HG002223HHS | NIH | National Human Genome Research Institute (NHGRI) U24HG010859HHS | NIH | NIH Office of the Director (OD) OD 010440HHS | NIH | NIH Office of the Director (OD) R24OD010943NHGRI NIH HHS U24 HG002223NHGRI NIH HHS U24 HG010859NIA NIH HHS R01 AG016636NICHD NIH HHS P50 HD105352NIH HHS P40 OD010440NIH HHS R24 OD010943
6 · The paper itself

Abstract

Experimental organisms such as the nematode

Indexed as

Caenorhabditis elegansNobel PrizeAnimalsUnited StatesCaenorhabditis elegansCaenorhabditis Genetics Center (CGC)model organism researchWormAtlasWormBase

Identifiers

PMID41284858
PMCPMC12685049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.