Evidence map›Paper›PMID 41284782›Full record

ArticleJournal of palliative care2026

Impact of Hydrocodone Rescheduling on Pharmaceutical Pain Management in End-of-Life Lung Cancer Patients.

Chan Shen, Mohammad Ikram, Shouhao Zhou, Roger Klein, James Douglas Thornton, Douglas Leslie

Abstract read
In one paragraph

Article in Journal of palliative care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chan ShenDepartment of Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.ORCID 0000-0001-5680-3134
Mohammad IkramDepartment of Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Shouhao ZhouDepartment of Public Health Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Roger KleinDepartment of Economics, Rutgers University, New Brunswick, NJ, USA.
James Douglas ThorntonDepartment of Pharmaceutical Health Outcomes and Policy, University of Houston College of Pharmacy, Houston, TX, USA.
Douglas LeslieDepartment of Public Health Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.

Funding

The effects of hydrocodone rescheduling on pain management of older lung cancer patientsR21CA277849 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SHEN, CHAN · 2022 to 2022
$471k
NCI NIH HHS R21 CA277849
6 · The paper itself

Abstract

ObjectiveLung cancer is the leading cause of cancer mortality in the USA, and terminal patients endure severe pain. In October 2014, hydrocodone was rescheduled from Schedule III to Schedule II to curb misuse, yet its specific impact on end-of-life lung cancer pain management remains unclear. The objective of this study is to evaluate the impact of hydrocodone rescheduling on pharmaceutical pain management among end-of-life lung cancer patients in the USA.MethodsWe conducted a retrospective study using SEER-Medicare data including 24,804 patients aged ≥66 with stage IV lung cancer who died between 2011 and 2019. We examined hydrocodone, opioid, NSAID, and antidepressant use in the last three months of life and used multivariable logistic and OLS regression to assess the effects of hydrocodone rescheduling and time trends, adjusting for demographic and clinical factors.ResultsHydrocodone was used by 47.5% of patients and any opioids by 75.4%. Although the hydrocodone rescheduling showed a nonsignificant immediate reduction in use (AOR = 0.92,

Indexed as

Analgesics, OpioidCancer PainHydrocodoneLung NeoplasmsPain ManagementTerminal CareAgedAged, 80 and overFemaleHumansMaleRetrospective StudiesSEER ProgramUnited StatesAnalgesics, OpioidHydrocodoneend of lifehydrocodone reschedulinglung canceropioid and nonopioid pharmacotherapypain managementSEER-Medicare data

Identifiers

PMID41284782
PMCPMC13234311

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.