Evidence map›Paper›PMID 41284467›Full record

ArticleThe American journal of gastroenterology2025

TRENDS IN THE ULCERATIVE COLITIS TO CROHN'S DISEASE INCIDENCE RATIO ARE DISTINCT BETWEEN EPIDEMIOLOGIC STAGES OF INFLAMMATORY BOWEL DISEASE.

Joseph W Windsor, Stephanie Coward, Lindsay Hracs, Joyce W Y Mak, Rupa Banerjee, Paulo G Kotze, Richard Gearry, Siew C Ng, Gilaad G Kaplan, Global IBD Visualization of Epidemiology Studies in the 21s,t Century (GIVES-21) Research Group

Abstract read
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In one paragraph

Article in The American journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Black tea-processedFrontiers in nutrition · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joseph W WindsorDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada .ORCID 0000-0002-7539-9103
Stephanie CowardDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada .ORCID 0000-0003-0675-7226
Lindsay HracsDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada .ORCID 0000-0002-8618-7544
Joyce W Y MakDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong , China.ORCID 0000-0001-5221-7349
Rupa BanerjeeIBD Center, Asian Institute of Gastroenterology, Hyderabad, India. International Organization for the study of Inflammatory Bowel Disease (IOIBD).
Paulo G KotzeHealth Sciences Postgraduate Program, Pontificia Universidade Católica do Paraná, Curitiba, Brazil. International Organization for the study of Inflammatory Bowel Disease (IOIBD).ORCID 0000-0002-9632-6691
Richard GearryDepartment of Medicine, University of Otago, Christchurch, New Zealand. International Organization for the study of Inflammatory Bowel Disease (IOIBD).
Siew C NgMicrobiota I-Center (MagIC), Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China. New Cornerstone Science Laboratory, The Chinese University of Hong Kong, Hong Kong, China. International Organization for the study of Inflammatory Bowel Disease (IOIBD).ORCID 0000-0002-6850-4454
Gilaad G KaplanDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada. International Organization for the study of Inflammatory Bowel Disease (IOIBD).ORCID 0000-0003-2719-0556
Global IBD Visualization of Epidemiology Studies in the 21s,t Century (GIVES-21) Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe ulcerative colitis (UC) to Crohn's disease (CD) incidence ratio varies across geography and time.

methodsWe analyzed UC:CD incidence ratios across three epidemiologic stages using generalized additive models for location, shape, and scale and pooled average annual percent changes (AAPCs) by meta-analysis.

resultsRatios significantly decreased: median 3.62 in stage 1, 1.82 in stage 2, 1.55 in stage 3; the incidence ratio stabilized in stage 3 (AAPC: -0.12; 95%CI: -0.66, 0.42). DISCUSSION: Decreasing UC:CD incidence ratios signal a rising burden of CD, underscoring the need to anticipate greater healthcare demand, including higher treatment costs and higher prevalence of complications.

Indexed as

Crohn’s diseaseepidemiologic transitionincidence ratioInflammatory bowel diseaseulcerative colitis

Identifiers

PMID41284467
PMCPMC13127728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.