Evidence map›Paper›PMID 41284414›Full record

ReviewBiochemistry2025

CRISPR Technology: Transforming the Future of Medicine and Diagnostics.

Kavita A Iyer, Rumiana Tenchov, Leilani M Lotti Diaz, Preeti Jain, Trupti Thite, Yi Deng, Qiongqiong Angela Zhou

Abstract readReview
In one paragraph

Review in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kavita A IyerA Division of the American Chemical Society, CAS, Columbus, Ohio 43210, United States.ORCID 0000-0002-8476-0036
Rumiana TenchovA Division of the American Chemical Society, CAS, Columbus, Ohio 43210, United States.ORCID 0000-0003-4698-6832
Leilani M Lotti DiazA Division of the American Chemical Society, CAS, Columbus, Ohio 43210, United States.ORCID 0000-0001-5955-9595
Preeti JainACS International India Pvt., Ltd., Pune 411044, India.
Trupti ThiteACS International India Pvt., Ltd., Pune 411044, India.ORCID 0009-0004-2194-1552
Yi DengA Division of the American Chemical Society, CAS, Columbus, Ohio 43210, United States.ORCID 0009-0001-4116-295X
Qiongqiong Angela ZhouA Division of the American Chemical Society, CAS, Columbus, Ohio 43210, United States.ORCID 0000-0001-6711-369X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this report, we examine the extensive research landscape of CRISPR with an emphasis on CRISPR therapeutics and showcase our results from an in-depth analysis of the most up-to-date scientific information consisting of more than 53,000 publications encompassing academic journal articles and patents, spanning nearly three decades, extracted from the CAS Content Collection. Our analysis indicates that cancer and infectious diseases are the most explored in the context of CRISPR. Identified gene targets associated with CRISPR-related publications are led by TP53, c-myc, and hemoglobin beta subunit (HBB). Among the many delivery methods, adeno-associated vectors (AAVs) appear to be highly explored. With >140 CRISPR-based therapeutics in the clinical development pipeline and billions of dollars in investment, the field of CRISPR continues to evolve rapidly. We also briefly discuss the ethical implications of CRISPR technology. While some fundamental challenges persist, the future of CRISPR is undoubtedly bright.

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsGene EditingGenetic TherapyAnimalsHumansNeoplasmsCasgevyCRISPRCRISPR diagnosticsgene editinggene therapylandscape analysis

Identifiers

PMID41284414
PMCPMC12713731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.