ReviewJournal of cellular and molecular medicine2025
Unveiling the Role of circRNAs in Pyroptotic Signalling: From Molecular Crosstalk to Disease Modulation.
Review in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Unveiling the Role of circRNAs in Pyroptotic Signalling: From Molecular Crosstalk to Disease Modulation.Journal of cellular and molecular medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Pyroptosis is a gasdermins-dependent programmed cell death (PCD) characterised by progressive cellular swelling and plasma membrane rupture (PMR). This process releases intracellular contents that amplify inflammatory cascades and immune activation, involving the pathogenesis of various disorders such as tumours, heart and vascular diseases, diabetic complications and inflammatory/infectious disorders. With the advancement of research, the regulatory role of noncoding RNA (ncRNA) in the pyroptosis pathway was delineated. Among, studies have demonstrated that circular RNAs (circRNAs) regulate the pyroptosis cascade mainly through three principal mechanisms: functioning as miRNA sponges, modulating protein activity and encoding functional polypeptides. Numerous circRNAs regulating pyroptosis have been characterised, indicating their significant role in this process and associated disease progression. This review systematically summarised current knowledge on the regulatory mechanisms of circRNAs in canonical, noncanonical and caspase-3/8-mediated pyroptosis pathways. We further discussed their pathophysiological roles in disease development and potential clinical applications, aiming to advance mechanistic understanding, facilitate clinical translation and inform diagnostic and therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.