Evidence map›Paper›PMID 41284324›Full record

ArticleAIDS (London, England)2026

Blood pressure trajectories among people with and without HIV in a U.S.-based prospective cohort study.

Leah M Sadinski, Jessie K Edwards, Michael E Herce, Christy L Avery, William C Miller, Ross J Simpson, Catalina Ramirez, Frank J Palella, Todd T Brown, Roger Detels and 11 more

Abstract readMulticenter Study
In one paragraph

Article in AIDS (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Leah M SadinskiUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Jessie K EdwardsUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Michael E HerceUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Christy L AveryUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
William C MillerUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Ross J SimpsonUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Catalina RamirezUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Frank J PalellaNorthwestern University, Chicago, IL.
Todd T BrownJohns Hopkins University, Baltimore, MD.
Roger DetelsUniversity of California, Los Angeles, Los Angeles, CA.
Jared W MagnaniUniversity of Pittsburgh, Pittsburgh, PA.
Emily B LevitanUniversity of Alabama at Birmingham, Birmingham, AL.
Margaret A FischlUniversity of Miami, Miami, FL.
Lauren F CollinsEmory University and the Grady Ponce de Leon Center, Atlanta, GA.
Gypsyamber D'SouzaJohns Hopkins University, Baltimore, MD.
Audrey FrenchUniversity of Illinois Chicago, Chicago, IL.
Phyllis C TienUniversity of California San Francisco and San Francisco Veterans Affairs Healthcare System, San Francisco, CA.
Adam ViscontiGeorgetown University, Washington, DC.
Jason LazarSUNY Downstate Health Sciences University, Brooklyn.
Kathryn AnastosAlbert Einstein College of Medicine, Bronx, NY, USA.
Michelle Floris-MooreUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIAID NIH HHS T32 AI070114NIMH NIH HHS P30 MH116867
6 · The paper itself

Abstract

backgroundPeople with HIV experience conventional and HIV-specific risk factors for increased blood pressure and may have different trajectories than people without HIV. Using data from the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS), we describe longitudinal patterns in blood pressure, hypertension, and vital status for people with HIV and without HIV.

methodsWe estimated longitudinal trajectories of systolic and diastolic blood pressure, pulse pressure, and mean arterial pressure using generalized estimating equations. Using multinomial logistic regression and Kaplan-Meier curves, we estimated the proportion of participants in four states corresponding to vital and hypertensive status.

resultsWe included men and women with HIV who reported antiretroviral therapy use (MACS: n  = 1555; WIHS: n  = 2765) and men and women without HIV (MACS: n  = 1671; WIHS: n  = 1145) between ages 20 and 70 from 1998 to 2019. Trajectory shapes were similar between people with and without HIV within cohorts. Men with and without HIV had similar blood pressure across ages. Women with HIV had lower blood pressure than those without HIV (average systolic difference -4.7 mmHg; 95% CI: -5.6, -3.8). Despite comparable average time alive without hypertension, people with HIV experienced higher mortality than those without HIV (risk at age 50, MACS: 13.1% vs. 8.1%; WIHS 33.3% vs. 9.6%).

conclusionBlood pressure trajectories were similar between people with and without HIV, although blood pressure was slightly lower for women with HIV. High mortality among people with HIV (vs. without) may have resulted in a lower proportion of people with hypertension at older ages.

Indexed as

Blood PressureHIV InfectionsHypertensionAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesRisk FactorsUnited StatesYoung Adultblood pressurecohort studyHIV epidemiologypeople with HIV

Identifiers

PMID41284324
PMCPMC13653486

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