Evidence map›Paper›PMID 41284294›Full record

ArticleJAMA network open2025

Condition-Specific Growth Charts for Children With Alagille Syndrome.

Koen Huysentruyt, Shannon M Vandriel, Mathieu Roelants, David A Piccoli, Kathleen M Loomes, Elizabeth B Rand, Noelle H Ebel, Jeffrey A Feinstein, Irena Jankowska, Piotr Czubkowski and 87 more

Erratum issuedAbstract readMulticenter Study
In one paragraph

Article in JAMA network open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Error in Nonbyline Author List.JAMA network open · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

97 authors.

Koen HuysentruytKindergastro-enterologie, hepatologie en nutritie, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Shannon M VandrielDivision of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.
Mathieu RoelantsEnvironment and Health, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
David A PiccoliDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia.
Kathleen M LoomesDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia.
Elizabeth B RandDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia.
Noelle H EbelDivision of Gastroenterology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
Jeffrey A FeinsteinDepartment of Pediatrics (Cardiology), Stanford University School of Medicine, Lucile Packard Children's Hospital, Palo Alto, California.
Irena JankowskaDepartment of Gastroenterology, Hepatology, Nutrition Disturbances and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.
Piotr CzubkowskiDepartment of Gastroenterology, Hepatology, Nutrition Disturbances and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.
Dorota Gliwicz-MiedzinskaDepartment of Gastroenterology, Hepatology, Nutrition Disturbances and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.
Emmanuel M GonzalesPediatric Hepatology and Liver Transplantation Unit, National Reference Centre for Rare Pediatric Liver Diseases, French Network for Rare Liver Disease, European Reference Network on Hepatological Diseases, Bicêtre Hospital, Assistance Publique-Hȏpitaux de Paris, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Emmanuel JacqueminPediatric Hepatology and Liver Transplantation Unit, National Reference Centre for Rare Pediatric Liver Diseases, French Network for Rare Liver Disease, European Reference Network on Hepatological Diseases, Bicêtre Hospital, Assistance Publique-Hȏpitaux de Paris, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Jérôme BouligandService de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpitaux Universitaires Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire de Bicêtre, Le Kremlin-Bicêtre, France.
Saul J KarpenDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia.
Rene RomeroDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia.
Henry C LinDivision of Pediatric Gastroenterology, Department of Pediatrics, Oregon Health and Science University, Portland.
Björn FischlerDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, Astrid Lindgren Children's Hospital, Karolinska University Hospital, CLINTEC, Karolinska Institutet, European Reference Network on Hepatological Diseases, Stockholm, Sweden.
Henrik ArnellDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Department of Women's and Children's Health, Karolinska Institutet, European Reference Network on Hepatological Diseases, Stockholm, Sweden.
Li-Ting LiThe Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
Jian-She WangThe Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
Rima FawazDepartment of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.
Silvia NastasioDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Kyung Mo KimDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, Seoul, Republic of Korea.
Seak Hee OhDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, Seoul, Republic of Korea.
Lorenzo D'AntigaPediatric Hepatology, Gastroenterology and Transplantation, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Emanuele NicastroPediatric Hepatology, Gastroenterology and Transplantation, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Ryan T FischerSection of Hepatology, Department of Gastroenterology, Children's Mercy Kansas City, Kansas City, Missouri.
Susan M SiewDepartment of Gastroenterology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Michael StormonDepartment of Gastroenterology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Chatmanee LertudomphonwanitDivision of Gastroenterology, Department of Pediatrics, Ramathibodi Hospital Mahidol University, Bangkok, Thailand.
Winita HardikarDepartment of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Melbourne, Victoria, Australia.
Sahana ShankarMazumdar Shaw Medical Center, Narayana Health, Bangalore, India.
James E SquiresDivision of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Shikha S SundaramSection of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics and the Digestive Health Institute, Children's Hospital of Colorado and University of Colorado School of Medicine, Aurora.
Catherine Larson-NathDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis.
Deirdre A KellyLiver Unit, Birmingham Women's and Children's Hospital, NHS Trust, and University of Birmingham, Birmingham, United Kingdom.
Jane HartleyLiver Unit, Birmingham Women's and Children's Hospital, NHS Trust, and University of Birmingham, Birmingham, United Kingdom.
Pinar BulutDivision of Pediatric Gastroenterology and Hepatology, Phoenix Children's Hospital, Phoenix, Arizona.
M Kyle JensenDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Primary Children's Hospital, University of Utah, Salt Lake City.
Catalina JaramilloDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Primary Children's Hospital, University of Utah, Salt Lake City.
Amin J RobertsDepartment of Paediatric Gastroenterology, Starship Child Health, Auckland, New Zealand.
Helen M EvansDepartment of Paediatric Gastroenterology, Starship Child Health, Auckland, New Zealand.
Étienne M SokalCliniques Universitaires Saint-Luc, Service De Gastroentérologie et Hépatologie Pédiatrique, Brussels, Belgium.
Tanguy DemaretCliniques Universitaires Saint-Luc, Service De Gastroentérologie et Hépatologie Pédiatrique, Brussels, Belgium.
Henkjan J VerkadeDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Richard J ThompsonInstitute of Liver Studies, King's College London, London, United Kingdom.
Bettina E HansenToronto General Hospital University Health Network, Toronto, Ontario, Canada.
Tim J ColeUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Binita M KamathDivision of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.
Global Alagille Alliance (GALA) Study Group
Dominique DebrayPediatric Liver Unit, National Reference Centre for Rare Pediatric Liver Diseases (Biliary Atresia and Genetic Cholestasis), French Network for Rare Liver Disease, European Reference Network on Hepatological Diseases, Necker-Enfants Malades Hospital, University of Paris, Paris, France.
Florence LacaillePediatric Gastroenterology-Nutrition and Hepatology Units, Necker-Enfants Malades Hospital, University of Paris, Paris, France.
Jernej BreceljPediatric Gastroenterology, Hepatology and Nutrition and Department of Pediatrics, Faculty of Medicine, University Medical Center Ljubljana, Ljubljana, Slovenia.
Nehal M El-KoofyDepartment of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed A ElmonemDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Way Seah LeeFaculty of Medicine, Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia.
Maria Camila SanchezPediatric Gastroenterology and Hepatology Division, Hospital Italiano Buenos Aires, Buenos Aires, Argentina.
Maria Lorena CavalieriPediatric Gastroenterology and Hepatology Division, Hospital Italiano Buenos Aires, Buenos Aires, Argentina.
Christina HajinicolaouDivision of Paediatric Gastroenterology, Chris Hani Baragwanath Academic Hospital, Department of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg, South Africa.
Kathleen B SchwarzRady Children's Hospital San Diego, Division of Pediatric Gastroenterology, University of California, San Diego.
Elisa CarvalhoPediatric Gastroenterology Department, Hospital da Crianca de Brasilia, Centro Universitario de Brasilia, Brasilia, Federal District, Brazil.
Nathalie RockSwiss Pediatric Liver Center, Division of Pediatric Specialties, Department of Pediatrics, Gynecology, and Obstetrics, University Hospitals Geneva and University of Geneva, Geneva, Switzerland.
Wikrom KarnsakulDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ruben E Quiros-TejeiraDepartment of Pediatrics, Children's Nebraska and University of Nebraska Medical Center, Omaha.
Seema AlamDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Gabriella NebbiaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Servizio di Epatologia Pediatrica, Milan, Italy.
Yael Mozer-GlassbergInstitute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Pamela L ValentinoGastroenterology and Hepatology Division, Department of Pediatrics, University of Washington, Seattle Children's Hospital, Seattle.
Ermelinda Santos-SilvaCentro Hospitalar Universitario de Santo Antonio, Centro Materno-Infantil do Norte Albino Aroso, Porto, Portugal.
Zerrin ÖnalPediatric Gastroenterology, Hepatology and Nutrition Department, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Antal Dezsofi-GottlFirst Department of Paediatrics, Semmelweis University, Budapest, Hungary.
Melina MelerePediatric Gastroenterology Service, Hospital da Crianca Santo Antonio, Universidade Federal de Ciencias da Saude de Porto Alegre, Complexo Hospitalar Santa Casa, Porto Alegre, Rio Grande do Sul, Brazil.
María Legarda TamaraPaediatric Gastroenterology Unit, Cruces University Hospital, Bilbao, Spain.
John EshunDepartment of Pediatric Gastroenterology, Le Bonheur Children's Hospital, The University of Tennessee Health Science Center, Memphis.
Aglaia ZellosMitera Children's Hospital, Athens, Greece.
Giuseppe IndolfiMeyer Children's University Hospital IRCCS, Florence, Italy.
Maria RogalidouDivision of Gastroenterology and Hepatology, "Aghia Sofia" Children's Hospital, First Department of Pediatrics, University of Athens, Athens, Greece.
Niviann BlondetGastroenterology and Hepatology Division, Department of Pediatrics, University of Washington, Seattle Children's Hospital, Seattle.
Pier Luigi CalvoPediatric Gastroenterology Unit, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria Citta' della Salute e della Scienza, Turin, Italy.
Marisa BerettaFaculty of Health Sciences, Wits Donald Gordon Medical Centre, University of the Witwatersand, Johannesburg, South Africa.
Andréanne N ZizzoChildren's Hospital, London Health Sciences Centre, Division of Paediatric Gastroentereology and Hepatology, Western University, London, Ontario, Canada.
Cigdem ArikanDepartment of Pediatric Gastroenterology and Organ Transplant, Koc University School of Medicine, Istanbul, Turkey.
Mureo KasaharaOrgan Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
Nanda KerkarMassachusetts General Hospital for Children, Boston.
Amal A AqulUniversity of Texas Southwestern Medical Center and Children's Health, Dallas.
Victorien M WoltersDepartment of Pediatric Gastroenterology, University Medical Center Utrecht, Utrecht, the Netherlands.
Raquel Borges PintoDivision of Pediatric Gastroenterology, Hospital Crianca Conceicao, Grupo Hospitalar Conceicao, Porto Alegre, Rio Grande do Sul, Brazil.
Jesus Quintero BernabeuPediatric Hepatology and Liver Transplant Department, Hospital Universiatri Vall d'Hebron, Barcelona, Spain.
Jennifer GarciaDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Miami Transplant Institute, University of Miami, Miami, Florida.
Sabina WiecekDepartment of Pediatrics, Medical University of Silesia in Katowice, Katowice, Poland.
Christos TzivinikosDepartment of Paediatric Gastroenterology, Al Jalila Children's Specialty Hospital, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Quais MujawarSection of Pediatric Gastroenterology, Department of Pediatrics, University of Manitoba, Winnipeg, Canada.
Carolina Jimenez-RiveraDivision of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Cristina Molera BusomsPediatric Gastroenterology Hepatology and Nutrition Unit, Hospital Sant Joan de Deu, Esplugues de Llobregat, Spain.
Cristina GonçalvesPediatric Gastroenterology/Hepatology Center, European Reference Network on Hepatological Diseases, Lisbon, Portugal.
Luis BujandaDepartment of Hepatology and Gastroenterology, Biodonostia Health Research Institute-Donostia University Hospital, Universidad del Pais Vasco, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas, San Sebastian, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Different degrees of growth delay have been reported in children with Alagille syndrome (ALGS), yet these patients are routinely evaluated using standard growth charts. Objective: To develop condition-specific growth charts for ALGS using modern statistical approaches. Design, Setting, and Participants: This case series used data from the international, multicenter Global Alagille Alliance (GALA) study accrued between May 14, 2018, and March 20, 2023. Children born at full term between January 1, 1997, and August 31, 2019, with a clinically and/or genetically confirmed ALGS diagnosis and their native liver were included. Data from children with a known history of prematurity were excluded for the development of the growth charts. Data were analyzed from March 25, 2023, to December 30, 2024. Exposure: Growth of children with Alagille syndrome. Main Outcomes and Measures: Generalized additive models for location scale and shape were fitted to generate percentile plots for weight and height relative to age and superimposed on US Centers for Disease Control and Prevention (CDC) growth charts to illustrate differences in growth patterns compared with children with typical development. Results: Data from 1204 children with ALGS in overlapping cohorts (median [IQR] gestational age, 38 [37-39] weeks) were analyzed (1204 in the weight cohort; 695 boys [57.7%]; 9855 weight observations; 995 with neonatal cholestasis [82.6%]; 306 receiving a liver transplant [25.4%]; 98 deaths [8.1%] and 1106 in the height cohort, 635 boys [57.4%]; 8464 height observations; 906 with neonatal cholestasis [81.9%]; 287 receiving a liver transplant [25.9%]; 86 deaths [7.8%]) were included for the modeling of the weight-for-age and height-for-age charts, respectively. The median birth weight was 2.8 kg (IQR, 2.5-3.0 kg) for boys and 2.6 kg (IQR, 2.4-2.9 kg) for girls. The median birth length was 48.0 cm (IQR, 46.0-50.0 cm) for boys and 47.0 cm (IQR, 45.0-49.0 cm) for girls. The weight-for-age and height-for-age growth charts for boys and girls with AGLS differed significantly from CDC growth charts. The estimated height at age 18 years corresponded to the 50th percentile was 171.5 cm for boys and 156.5 cm for girls on the condition-specific charts vs 176 cm and 163 cm, respectively, on the CDC growth charts. Conclusions and Relevance: These findings suggest that condition-specific growth charts for ALGS may provide a crucial tool for clinicians to evaluate growth and aid in decision-making around listing children for liver transplant.

Indexed as

Alagille SyndromeGrowth ChartsBody HeightBody WeightChildChild, PreschoolFemaleHumansInfantInfant, NewbornMale

Identifiers

PMID41284294
PMCPMC12645329

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