Evidence map›Paper›PMID 41284225›Full record

SynthesisUnited European gastroenterology journal2026

High Burden of Pancreatic Surgery for Intraductal Papillary Mucinous Neoplasia With Low-Grade Dysplasia and Benign Cysts: A Systematic Review and Meta-Analysis.

Samuel Tanner, Priyata Dutta, Elit Quingalahua, Jean M Chalhoub, Fadi Hawa, Antonio Facciorusso, Gabriele Capurso, Un-Jung Lee, Jorge D Machicado

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in United European gastroenterology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. IPMN Management, Time to Move Beyond Surgical Thresholds.United European gastroenterology journal · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuel TannerDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-1204-1550
Priyata DuttaDepartment of Internal Medicine, Trinity Health, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-7954-9511
Elit QuingalahuaDepartment of Pediatrics, Central Michigan University, Saginaw, Michigan, USA.
Jean M ChalhoubDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, New York, USA.
Fadi HawaDivision of Gastroenterology and Hepatology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Antonio FacciorussoGastroenterology Unit, Department of Experimental Medicine, Università del Salento, Lecce, Italy.ORCID https://orcid.org/0000-0002-2107-2156
Gabriele CapursoPancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, and "Vita-Salute" San Raffaele University, Milan, Italy.
Un-Jung LeeBiostatistics Unit, Office of Academic Affairs, Northwell Health, New Hyde Park, New York, USA.ORCID https://orcid.org/0000-0002-6097-6414
Jorge D MachicadoDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraductal papillary mucinous neoplasms with low-grade dysplasia (IPMNs w/LGD) and benign cysts, including serous cystadenomas (SCAs), are common pancreatic cystic lesions (PCLs) that are better managed conservatively. The burden of patients who undergo surgical resection for these cysts is unknown. Our study aims to estimate the global prevalence of surgical resections for IPMNs w/LGD and benign cysts, as well as the pre-operative misclassification rate among all resected PCLs.

methodsWe searched the literature through September 2023 to identify full-text articles that reported the surgical histopathology of resected PCLs. A proportional meta-analysis was performed using a random-effects model, with prevalence estimates reported as pooled proportions. Subgroup analysis and meta-regression were performed based on use of endoscopic ultrasound (EUS), years of enrollment, and geographic location.

resultsSixteen studies (n = 5830) were identified. Among all surgically resected PCLs, 24% were IPMNs w/LGD (95% CI: 18%-32%), 16% were SCAs (95% CI 13%-19%), 4% were other benign cysts (95% CI: 3%-6%), and 24% were pre-operatively misclassified (95% CI: 16%-34%). Of the resected IPMNs, 62% had LGD (95% CI: 51%-71%). An increasing use of pre-operative EUS is associated with a lower prevalence of resected SCAs (p < 0.05) but has not impacted the rate of resections for IPMNs w/LGD. The pre-operative misclassification of PCLs has significantly decreased over time (p < 0.01), although not significantly influenced by increasing EUS utilization or geographic location.

conclusionOne quarter of PCLs are pre-operatively misclassified and ∼44% are surgically resected for benign cysts or IPMNs w/LGD. Implementation of advanced diagnostic tools might improve pre-operative classification and reduce overtreatment of PCLs.

Indexed as

Carcinoma, Pancreatic DuctalCystadenoma, SerousPancreatectomyPancreatic CystPancreatic Intraductal NeoplasmsPancreatic NeoplasmsEndosonographyHumansPrevalencebenign cystIPMNlow‐grade dysplasiapancreas cystpancreas surgerypancreatectomyserous cystadenoma

Identifiers

PMID41284225
PMCPMC12812000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.