Evidence map›Paper›PMID 41284212›Full record

ArticleInfection2026

Severe destruction in vertebral osteomyelitis - risk factors and survival.

Jan Philipp Hockmann, Nikolaus Kernich, Krishnan Sircar, Peer Eysel, Ada Hoffmann, Dorothee Jochimsen, Norma Jung, Ayla Yagdiran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jan Philipp HockmannDepartment of Orthopaedic Surgery, Traumatology and Plastic-Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Joseph-Stelzmann-Str. 24, 50931, Cologne, Germany. jan.hockmann@uk-koeln.de.ORCID http://orcid.org/0000-0002-6203-8616
Nikolaus KernichDepartment of Orthopaedic Surgery, Traumatology and Plastic-Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Joseph-Stelzmann-Str. 24, 50931, Cologne, Germany.
Krishnan SircarDepartment of Orthopaedic Surgery, Traumatology and Plastic-Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Joseph-Stelzmann-Str. 24, 50931, Cologne, Germany.
Peer EyselDepartment of Orthopaedic Surgery, Traumatology and Plastic-Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Joseph-Stelzmann-Str. 24, 50931, Cologne, Germany.
Ada HoffmannInstitute for Medical Microbiology, Immunology and Hygiene (IMMIH), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Dorothee JochimsenDivision of Infectious Diseases, Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Norma JungDivision of Infectious Diseases, Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Ayla YagdiranDepartment of Orthopaedic Surgery, Traumatology and Plastic-Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Joseph-Stelzmann-Str. 24, 50931, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe treatment of vertebral osteomyelitis (VO) is multifaceted. In most cases, patients are treated conservatively. In the past, it has already been shown that the quality of life is improved by surgery compared to conservative treatment. Recently it was also shown that surgical treatment of VO improves recurrence and mortality. Indications of a surgical approach can be relative or absolute. Absolute indications include, above all, severe bony destruction. The aim of this study is to identify risk factors for severe destruction in comparison to minor to or not to moderate destruction.

methodsThis monocentric study included 355 patients with VO from the DWG- and the former European Spine Tango-Registry. The primary aim was to analyze the risk factors for severe destruction, the secondary aim was to determine the outcomes between the different degrees of severity.

resultsThe prediction model for severe destruction with the factors age ≥ 65 years, gender, CRP ≥ 10 mg/L, an ASA class above two, a BMI ≥ 25 kg/m

conclusionsMultimorbid patients with native VO exhibit more severe bony destruction. These patients are high-risk VO patients with an increased 1-year mortality rate. Therefore an early indication for surgical treatment may proof advantageous.

Indexed as

OsteomyelitisSpineAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRisk FactorsDestructionObesityPathogensPostoperativeRisk factorsSurvivalVertebral osteomyelitis

Identifiers

PMID41284212
PMCPMC13021681

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.