ArticleDiscover oncology2025
The analysis of TOP2A as a potential target for predicting the prognosis of brain glioma in the TCGA database and in single-center study.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of extracellular vesicles on malignant tumours: Mechanisms and clinical findings (Review).Oncology letters · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundGlioma is a neurological tumor with a high degree of malignancy and a poor survival prognosis. The development of bioinformatics-related databases has helped us to further analyze the correlation between genes and tumors. In previous studies, through GSVA enrichment analysis, we obtained 17 core genes (TOP2A, KIF20A, CCNB2, AURKA, KIF11, CDK1, BUB1B, CCNA2, BUB1, CDC20, CDCA8, TPX2, KIF2C, POLA2, POLE2, POLA1 and POLE) that affect the survival prognosis of patients, and since TOP2A order is the highest we found that TOP2A is associated with the clinical features of brain gliomas through a series of bioinformatics databases and statistical analyses. After undergoing bioinformatics analysis, in this study, we further explore the correlation between TOP2A and the clinical samples of real-world glioma patients, so as to analyze the relationship between TOP2A expression and the survival prognosis of patients. It is worth mentioning that only malignant gliomas were designed in this study, and benign gliomas were not included in the scope of this study. MATERIALS AND
methodsDownloaded glioma data from TCGA database. COX regression analysis assessed clinical relevance. Experimental verification by immunohistochemistry. GSEA analyzes relevant biological functions.
resultsFocused on the correlation between TOP2A and glioma, and transported 161 glioma tissue wax blocks from the First Affiliated Hospital of Anhui Medical University, analyzed the correlation between gene expression and clinical data in the real world, and confirmed that it was closely related to the survival prognosis of glioma patients.
conclusionsThrough bioinformatics analysis and immunohistochemical experiments combined with real-world patient data, it was confirmed that TOP2A expression was closely related to patient prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.