Evidence map›Paper›PMID 41284065›Full record

ArticleInternational ophthalmology2025

Fungal keratitis: Does antifungal Resistance Influence the outcome?

Pratima Vishwakarma, Lakshminarayanan Gowtham, Esther Sheba, Joveeta Joseph, Bhupesh Bagga

Abstract read
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Current status on antimicrobial resistance in keratitis.Indian journal of ophthalmology · 2026
    Article
  2. Chelidonic acid amelioratesFrontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pratima VishwakarmaThe Ramoji Foundation Centre for Ocular Infections, The Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Lakshminarayanan GowthamDr. Chigurupati Nageswara Rao Ocular Pharmacology Research Centre, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Esther ShebaJhaveri Microbiology Centre, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Joveeta JosephJhaveri Microbiology Centre, LV Prasad Eye Institute, Hyderabad, India. joveeta@lvpei.org.
Bhupesh BaggaThe Ramoji Foundation Centre for Ocular Infections, The Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India. bhupesh@lvpei.org.

Funding

Hyderabad Eye Research Foundation LEC-BHR-P-08-22-933
6 · The paper itself

Abstract

purposeTo correlate clinical outcomes of fungal keratitis with in vitro antifungal susceptibility profiles.

methodsThis retrospective case series included microbiologically confirmed fungal keratitis cases treated with antifungals for ≥ 1 week (August-December 2022). Cases with early therapeutic penetrating keratoplasty (TPK) (< 1 week) or mixed etiology were excluded.

resultsRecords of 83 patients were reviewed. Medical cure was achieved in 48 (57.8%) patients, while 35 (42.2%) underwent TPK. Fusarium sp.(41%) and Aspergillus sp.(33.7%) were most prevalent. Several other fungi were isolated like Curvularia, Acremonium, Lasiodiplodia, etc. (25.3%). Fusarium showed lower natamycin resistance (35.3%) than Aspergillus (50%) (p = 0.2429) species; but higher resistance to voriconazole, itraconazole, and posaconazole (V, 82.4%; I, 66.7%; P, 82.4%) versus Aspergillus (V, 39.3%; I, 26.9%; P, 32.1%) (p < 0.005). Among cases with milder severity (infiltrate < 4 mm) (n = 40), higher natamycin resistance was associated with greater rate of TPK (60%) versus medical resolution (26.7%) (p = 0.123).

conclusionAlthough the outcomes are multifactorial, antifungal resistance seems to influence the prognosis of fungal keratitis.

Indexed as

Antifungal AgentsDrug Resistance, FungalEye Infections, FungalFungiKeratitisAdultAgedAged, 80 and overFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedRetrospective StudiesAntifungal AgentsAntifungal resistanceAntifungal susceptibilityFungal keratitis

Identifiers

PMID41284065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.