SynthesisEuropean archives of psychiatry and clinical neuroscience2026
Bed nucleus of the stria terminalis deep brain stimulation in treatment-refractory obsessive-compulsive disorder: a systematic review.
Synthesis in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObsessive-compulsive disorder (OCD) is one of the most disabling psychiatric disorders. Despite the available pharmacological and psychotherapeutic treatments, symptoms persist to a severe degree in a large number of patients who are considered refractory to treatment. For some of them, deep brain stimulation (DBS) offers an appropriate therapeutic method. The purpose of this systematic review is to summarize the existing knowledge about the effectiveness of the stimulation of the bed nucleus of stria terminalis (BNST). MATERIALS AND
methodsA thorough literature review regarding BNST DBS for the treatment of OCD was conducted. The following sequence ‘’ (Obsessive-Compulsive Disorder) OR (OCD)) AND ((Deep Brain Stimulation) OR (DBS)) AND ((Bed Nucleus of Stria Terminalis) OR (BNST)) ‘’ was used when searching in the two databases, MEDLINE and Scopus.
resultsIn total, 8 studies were found after the application of the inclusion and exclusion criteria. Overall, 68 patients were included, with a mean age of surgery 41.2 years old. At the last follow-up, the mean reduction of the Yale-Brown Obsessive-Compulsive Scale (YBOCS) compared to baseline was 45.6% with a range across the studies of 38% to 53%. In total, 46 participants were considered responders. The median stimulation parameters were an amplitude of 4.7 V, a frequency of 130 Hz, and a pulse width of 129.2 µs. Finally, there was improvement of depressive and anxiety symptoms, as well as quality of life, without any significant cognitive impairment.
conclusionDBS of the BNST in treatment-refractory OCD appears as a safe and effective treatment option.
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Registered trials
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