ArticleInternational ophthalmology2025
Long-term effectiveness of the trabecular micro-bypass (iStent): 3-year real world data in glaucoma and ocular hypertension.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study evaluates the effectiveness and safety profile of the iStent inject® combined with cataract surgery, with 3 years of follow-up in a large patient cohort (n = 464) of various glaucoma phenotypes and disease severity.
methodsThis retrospective, single-arm, multi-surgeon study included eyes undergoing iStent inject® with cataract surgery. Inclusion criteria was symptomatic cataract in addition to uncontrolled intraocular pressure (IOP) on ≥ 2 IOP lowering agents or contraindication and/or intolerance to IOP lowering medication. IOP, medications, safety profile and cumulative success rates were assessed.
resultsThe mean IOP was 14.8 ± 4.5 mmHg at 3 years, compared to 18.3 ± 5.8 mmHg preoperatively, an IOP reduction of 19.1% (P < 0.001). The mean number of IOP lowering medications was 1.84 ± 1.40 at 3 years, compared to 2.49 ± 1.12 medications preoperatively. At 3 years 24% of eyes were medication free compared to 3% of eyes preoperatively (P < 0.001). At 3 years the cumulative probability of eyes achieving complete success; an IOP reduction of ≥ 20% and IOP 6-21 mmHg without medication was 37% and the cumulative probability of achieving this with medication (qualified success) was 67%. No cases of endophthalmitis, hypotony or other sight threatening complications were recorded. 5% of eyes required further glaucoma procedures.
conclusionsThis large, real-world cohort demonstrates a significant and sustained IOP reduction with an improvement in medication burden 3 years after iStent inject® and phacoemulsification. An excellent safety profile was displayed with a low rate of further glaucoma surgery required.
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