ArticleActa diabetologica2026
Red cell distribution width positively correlates with 10-year risk of cardiovascular disease among people with type 1 diabetes as assessed by the Steno Type 1 Risk Engine.
Article in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionWe evaluated the association between Red Cell Distribution Width (RDW) and predicted 10-year cardiovascular disease (CVD) risk, as estimated by the Steno Type 1 Risk Engine (ST1RE), in individuals with type 1 diabetes (T1D).
methodsWe conducted a retrospective analysis of 342 adults with T1D duration > 5 years, (163 women, 179 men) from a tertiary Diabetes Center electronic database. Participants were stratified into tertiles of RDW: Group 1 (G1: < 12.6), Group 2 (G2: 12.6-13.2), and Group 3 (G3: >13.2).
resultsHigher RDW was associated with older age and longer diabetes duration. The prevalence of microvascular complications did not differ across RDW tertiles. Predicted 10-year CVD risk (ST1RE 10Y) increased with higher RDW: median (IQR) 4.5 (3.2-6.1) in G1, 4.5 (2.9-7.2) in G2, and 6.2 (3.5-12.0) in G3 (p < 0.01). In multiple linear regression, RDW was positively associated with ST1RE 10Y, (β = 1.13;95% CI, 0.57-1.70; p < 0.01; R
conclusionOur results suggest that RDW is independently associated with predicted 10-year CVD risk in individuals with T1D. These findings support RDW as a potential marker for cardiovascular risk stratification. However, external validation is required before clinical application.
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