ArticleJournal of the American Chemical Society2025
Entropy-Driven Amino Acid-Based Coacervates with Enzyme-Free Metabolism and Prebiotic Robustness.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Symmetry-Guided Optical Control of Dynamic 1D Protein Self-Assembly and Precise In Vitro Initiation of Biomolecular Condensation.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Programming Multidomain Peptides With Molecular Frustration Into Biomolecular Condensates.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Patchy Membrane-Directed Multiphase Complex Coacervation.Journal of the American Chemical Society · 2026Article
- Programmable Multiphasic Condensates Formed via Evaporation-Induced Phase Separation of Minimal Peptide Model.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase-Separation-Based Intelligent Drug Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Diastereomeric Configuration Modulates Liquid-Liquid Phase Separation and Catalysis in Minimalist Dipeptide Coacervates.Angewandte Chemie (International ed. in English) · 2026Article
- Origins of the Intrinsic Redox Activity of Biomolecular Condensates.Journal of the American Chemical Society · 2026Article
- Enantiopurity-Dependent Peptide Coacervates and Asymmetric Organocatalysis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protocells capable of nonenzymatic metabolism and environmental adaptation are essential models for understanding the emergence of cellular life. However, existing protocell designs often lack the robustness or prebiotic relevance to explain how functional supramolecular assemblies could have formed under early Earth conditions. In this study, we demonstrate that simple amino acid derivatives, observed on extraterrestrial bodies and under simulated prebiotic Earth conditions, undergo entropy-driven liquid-liquid phase separation to form membraneless protocells through a self-coacervation process. The synergistic effect of selective enrichment of metabolites and interfacial acceleration in these coacervate microdroplets enhances enzyme-free reactions, including sulfur metabolism and prebiotic pigment synthesis. The protocells are stabilized by water-mediated hydrogen-bonding networks and exhibit exceptional resilience to prebiotically plausible stressors─such as high salinity (up to 4.0 M NaCl), high concentrations of divalent cations (4.0 M Mg
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.