Evidence map›Paper›PMID 41283704›Full record

ArticleJournal of medicinal chemistry2025

Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2

Pedro Medina, Modesto Orozco, Montserrat Terrazas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pedro MedinaInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.
Modesto OrozcoInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.ORCID 0000-0002-8608-3278
Montserrat TerrazasDepartment of Inorganic and Organic Chemistry, Organic Chemistry Section, Institute of Biomedicine, University of Barcelona (IBUB), Barcelona 08028, Spain.ORCID 0000-0001-8614-5777

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ionizable lipid nanoparticles (LNPs) have enabled significant advances in oligonucleotide (ON) therapeutics, resulting in the approval of the short interfering RNA (siRNA)-based formulation Onpattro. However, achieving cell-specific delivery remains challenging. We have developed palmitate-containing ionizable LNPs functionalized with (i) octreotide (Oct), targeting somatostatin receptor type 2 (SSTR2)-expressing tumor cells, and (ii) penetratin (RK16), enhancing intracellular uptake. This dually decorated LNP codelivered two siRNAs targeting tumor-promoting genes (heat shock protein 27 (Hsp27) and human epidermal growth factor receptor 2 (HER2)) into HER2

Indexed as

Breast NeoplasmsErb-b2 Receptor Tyrosine KinasesHSP27 Heat-Shock ProteinsNanoparticlesPalmitatesRNA, Small InterferingCell Line, TumorFemaleHumansLipidsOctreotideReceptors, SomatostatinERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesHSP27 Heat-Shock ProteinsLipidsOctreotidePalmitatesReceptors, SomatostatinRNA, Small Interfering

Identifiers

PMID41283704
PMCPMC12703748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.