ArticleNanoscale2025
Water-soluble N-heterocyclic carbene stabilized gold nanoparticles by top-down synthesis: performance in catalysis and photoacoustic imaging.
Article in Nanoscale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Application Advances of Gold Nanoparticles in Cancer Theranostics: From Physicochemical Mechanisms to Multifunctional Nanoplatforms.International journal of molecular sciences · 2026Review
- Current status and future challenges of transition-metal oxides as enzyme-mimetics for detection of clinically relevant biomarkers: a comprehensive review.Mikrochimica acta · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-heterocyclic carbenes (NHCs) have emerged as effective capping ligands for gold nanoparticles (AuNPs), offering improved stability and flexibility compared to sulfur-based alternatives. Two synthetic approaches, 'bottom-up' (BU) and 'top-down' (TD), have been described; however, comparative studies remain scarce. Herein, we report the TD-synthesized water-soluble NHC-stabilized AuNPs (NHC@AuNPs) for catalysis in water and biomedical applications, exhibiting exceptional stability in physiologically relevant conditions. Further, the catalytic ability of TD-NPs in model reactions was compared to their BU counterparts featuring the same NHC ligands. In detail, the catalysts were tested for the reduction of 4-nitrophenol and resazurin, as well as for the biomimetic oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in aqueous conditions. The TD-NPs also showed distinct advantages over the BU NPs as contrast agents in photoacoustic imaging (PAI), further highlighting the differences between the two families of colloids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.