ArticlePathophysiology : the official journal of the International Society for Pathophysiology2025
Improved Rat Heart Preservation Using High-Pressure Gaseous Perfusion with Oxygen-Xenon Mixture.
Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo address limitations in static cold storage (SCS) of donor hearts, we developed the High-Pressure Gaseous Perfusion without Fluidic Preservation Media (HIPPER) method, along with the necessary equipment for its application.
methods33 Wistar rat hearts were split into five groups: (Control) static cold storage (SCS) in HTK solution, (Exp) HIPPER using oxygen-xenon gas mixtures of varying ratios ("Gas-A": 1/9, "Gas-B": 9/1, and "Gas-C": 1/1), and (Air) HIPPER using air. Hearts were preserved for six hours, followed by a one-hour Langendorff assessment.
resultsBeating was restored in 4/10 Control hearts, 15/15 Exp hearts across all gas mixtures (
conclusionsas evidenced by both quantitative and qualitative data, HIPPER consistently outperformed SCS following six hours of storage of rat heart regardless of the gas mixture, highlighting its potential as a more robust preservation method.
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