Altered Transcriptome Signature in Primary Human Myotubes Exposed to Inclusion Body Myositis Serum: A Pilot Case Comparison of Anti-cN1A Positive and Negative Sera.

Nataliya Slater, Abha Chopra, Ramesh Ram, Abbie Adams, Frank L Mastaglia, Merrilee Needham, Jerome D Coudert

Abstract read

In one paragraph

Article in Muscles (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nataliya SlaterPersonalised Medicine Center, School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0002-9979-6074

Abha ChopraPersonalised Medicine Center, School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0001-5008-9080

Ramesh RamPersonalised Medicine Center, School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0002-4827-4778

Abbie AdamsPersonalised Medicine Center, School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA 6150, Australia.

Frank L MastagliaPerron Institute for Neurological and Translational Science, Nedlands, WA 6009, Australia.

Merrilee NeedhamPersonalised Medicine Center, School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0001-6591-1444

Jerome D CoudertPersonalised Medicine Center, School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0001-6081-8494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inclusion body myositis (IBM) is a late-onset, treatment-resistant inflammatory myopathy. Approximately half of IBM patients develop autoantibodies against cytosolic 5'-nucleotidase 1A (cN1A), but their role in disease pathogenesis remains unclear. This pilot study examined the effects of anti-cN1A-positive IBM serum on human primary myotubes' transcriptome profile, using anti-cN1A-negative IBM and healthy sera as controls. Exposure to anti-cN1A-positive serum altered the expression of 1126 genes, with upregulation of adaptive immune response genes, notably

Indexed as

anti-cN1Aautoantibodiescytosolic 5′-nucleotidase 1Ainclusionbody myositisinflammatory myopathyNT5C1Aprimary human myotubes

Identifiers

PMID41283441

DOI10.3390/muscles4040053

PMCPMC12641819

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.