Evidence map›Paper›PMID 41283369›Full record

ArticleInternational journal of neonatal screening2025

Cord Blood-Based Neonatal Screening for Hemoglobinopathies in Northern Tunisia.

Houyem Ouragini, Nizar Ben Halim, Sana Zitouni, Dorra Chaouachi, Imen Boudrigua, Naima Saidani, Imen Kraiem, Amira Ayachi, Salem Abbes, Mechaal Mourali and 1 more

Abstract read
In one paragraph

Article in International journal of neonatal screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Houyem OuraginiLaboratory of Molecular and Cellular Hematology, LR16IPT07, Institut Pasteur de Tunis, University of Tunis ElManar, Tunis 1002, Tunisia.ORCID 0000-0003-2427-2804
Nizar Ben HalimLaboratory of Physiopathology, Alimentation and Biomolecules, LR17ES03, Higher Institute of Biotechnology, Sidi Thabet, University of Manouba, Ariana 2020, Tunisia.
Sana ZitouniLaboratory of Molecular and Cellular Hematology, LR16IPT07, Institut Pasteur de Tunis, University of Tunis ElManar, Tunis 1002, Tunisia.
Dorra ChaouachiLaboratory of Molecular and Cellular Hematology, LR16IPT07, Institut Pasteur de Tunis, University of Tunis ElManar, Tunis 1002, Tunisia.
Imen BoudriguaLaboratory of Molecular and Cellular Hematology, LR16IPT07, Institut Pasteur de Tunis, University of Tunis ElManar, Tunis 1002, Tunisia.
Naima SaidaniDepartment of Gynecology and Obstetrics, Habib Bougatfa Hospital, Bizerte 7000, Tunisia.
Imen KraiemLaboratory of Molecular and Cellular Hematology, LR16IPT07, Institut Pasteur de Tunis, University of Tunis ElManar, Tunis 1002, Tunisia.
Amira AyachiDepartment of Gynecology and Obstetrics, Habib Bougatfa Hospital, Bizerte 7000, Tunisia.
Salem AbbesLaboratory of Molecular and Cellular Hematology, LR16IPT07, Institut Pasteur de Tunis, University of Tunis ElManar, Tunis 1002, Tunisia.
Mechaal MouraliDepartment of Gynecology and Obstetrics, Habib Bougatfa Hospital, Bizerte 7000, Tunisia.
Samia MenifLaboratory of Molecular and Cellular Hematology, LR16IPT07, Institut Pasteur de Tunis, University of Tunis ElManar, Tunis 1002, Tunisia.

Funding

Tunisian Ministry of Higher Education and Scientific Research LR16IPT07
6 · The paper itself

Abstract

Hemoglobinopathies represent a major public health concern in Tunisia. Although early diagnosis is essential, systemic neonatal screening has not yet been implemented at the national level. We conducted a screening study in Northern Tunisia (Bizerte region) using cord blood samples. Complete blood counts and hemoglobin analysis by capillary electrophoresis were performed. Samples showing abnormal profiles (HbBart's, HbS, HbC, or HbA < 20%) underwent molecular testing. Correlations between hematological parameters, hemoglobin fractions, and β mutation types were assessed. Among 328 neonatal cord blood samples analyzed, we detected 3 silent α

Indexed as

capillary electrophoresismolecular analysisnewborn screeningsickle cell diseasethalassemia

Identifiers

PMID41283369
PMCPMC12641932

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.