Evidence map›Paper›PMID 41283361›Full record

ReviewInternational journal of neonatal screening2025

Celebrating 50 Years of Nationwide Newborn Screening in Hungary-Review, Current Situation, and Future Directions.

Péter Monostori, Ildikó Szatmári, Ákos Baráth, János Bókay, Marianna Csenki, Zsolt Galla, Balázs Gellén, Nóra Grecsó, Eszter Gyüre, Zita Halász and 14 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of neonatal screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Péter MonostoriMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.ORCID 0000-0003-3591-6054
Ildikó SzatmáriMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.ORCID 0000-0003-1040-145X
Ákos BaráthMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.
János BókayMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Marianna CsenkiDepartment of Medical Genetics, University of Szeged, Szőkefalvi-Nagy Béla u. 4/B, H-6720 Szeged, Hungary.
Zsolt GallaMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.ORCID 0000-0002-9166-1212
Balázs GellénMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.
Nóra GrecsóMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.
Eszter GyüreMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.
Zita HalászMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Krisztina HegedűsMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Judit KincsMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Erika KissMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Magdolna KósaMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.ORCID 0000-0002-0642-9882
István LénártMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.
Andrea PálmayMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Gábor RáczMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.
Hajnalka SzabóMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.
Léna SzabóMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Viktória TőkésiMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Andrea XueMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Petra ZsideghMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Attila József SzabóMetabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, H-1083 Budapest, Hungary.
Csaba BereczkiMetabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Korányi Fasor 14-15, H-6720 Szeged, Hungary.

Funding

University of Szeged Open Access Fund 7786
6 · The paper itself

Abstract

Newborn screening (NBS), one of the most important public health care prevention programs, aims at the early identification of asymptomatic newborns at increased risk for inherited disorders, facilitating timely intervention to reduce morbidity and mortality. NBS in Hungary is celebrating the 50th anniversary of the nationwide implementation of screening for phenylketonuria and galactosemia, as well as the 40th anniversary of congenital hypothyroidism screening. The present paper reviews the early years, the present situation, and future perspectives for the Hungarian NBS program. Today, screening for 27 disorders (opt-out) plus spinal muscular atrophy (opt-in) is supported by two centralized and well-equipped laboratories in Budapest and Szeged, in-depth laboratory knowledge, a robust follow-up system, and governmental financial support. Since 1975, 3,289 patients have been confirmed with a screened condition from over 5.6 million newborns screened. The 50-year anniversary of the Hungarian NBS program highlights the dedication of both past and current professionals, ongoing advancements in analytical methods and laboratory information management systems, and alignment with international standards. The equitable provision of screening services continues to be prioritized for all newborns nationwide and within the broader Euro-regional context.

Indexed as

diagnosticsinborn errors of metabolisminherited disordersmass spectrometrynewborn screening

Identifiers

PMID41283361
PMCPMC12641645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.