Evidence map›Paper›PMID 41283292›Full record

ArticleEpidemiologia (Basel, Switzerland)2025

Babesiosis and Malaria in the United States: Epidemiology, Research Funding, Medical Progress, & Recommendations for Improvement.

Ryan P Jajosky, Wenhui Li, Audrey N Jajosky, Philip G Jajosky, Sean R Stowell

Abstract read
In one paragraph

Article in Epidemiologia (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryan P JajoskyJoint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, 630E New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.ORCID 0000-0001-8458-7635
Wenhui LiJoint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, 630E New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Audrey N JajoskyDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14586, USA.ORCID 0000-0002-8265-2496
Philip G JajoskyBiconcavity Inc., Lilburn, GA 30047, USA.ORCID 0000-0002-1034-0127
Sean R StowellJoint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, 630E New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Funding

Etiology of naturally-occurring anti-ABO antibodiesK08HL171877 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Ryan P Jajosky · 2024 to 2026
$505k
NHLBI NIH HHS K08 HL171877NIH HHS 5K08HL171877-02
6 · The paper itself

Abstract

backgroundBabesiosis and malaria are infectious diseases caused by the intraerythrocytic parasites

methodsGiven similarities in the target cell of infection, data about babesiosis and malaria cases in the US were obtained from the Centers for Disease Control and Prevention (CDC). Research funding was quantified using National Institutes of Health (NIH) data, and medical progress was evaluated through a literature review.

resultsOver the 5-year span of 2018-22, there were 9799 and 7722 confirmed babesiosis and malaria cases, respectively. Confirmed babesiosis cases exceeded malaria cases in 4 of 5 years. In 2022, babesiosis and malaria data were either not reported or unavailable to the CDC by ten and one US state(s), respectively. Regarding babesiosis, it is likely that the vast majority of cases were due to domestically acquired

conclusionsIn the US from 2018-22, there were more babesiosis cases and deaths than malaria. Decades of robust CDC and NIH funding for malaria led to its elimination from the US, improved medical knowledge and interventions, and reduced foreign morbidity and mortality. These data suggest that leveraging similar approaches used for malaria, including increased NIH and CDC funding for babesiosis, would likely lead to progress (e.g., improved treatment). Babesiosis qualifies as both a rare and an orphan disease.

Indexed as

CDCdisease burdenemerging infectious diseasesforeign aidglobal healthhealthcare economicshematologymorbidity and mortalityNational Center for Emerging and Zoonotic Infectious Diseases (NCEZID)neglected diseasesNIHorphan diseasesparasitologyrare diseasesresearch prioritiesunderfundingUS public health

Identifiers

PMID41283292
PMCPMC12641916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.