ArticleACS applied materials & interfaces2025
A Bioinspired Mastoparan Exhibits Concentration-Dependent Anti-Bacterial Activity via Membrane Disruption.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
Antimicrobial peptides are widely investigated in the literature, but their mechanism of action and effects on lipid membranes are not completely understood from a physicochemical perspective. In this study, we employed a bioinspired mastoparan from wasp venom, mast-MO, and characterized its interactions with model lipid membranes, either as a supported lipid bilayer or as free-standing vesicles in solution. An array of complementary physicochemical characterization techniques was employed to study the surface activity of the peptide alone and how its adsorption affects lipid membrane properties in terms of lateral organization and integrity. We found that peptide action is related to its intrinsic surface activity, resulting in disrupted lipid packing of supported membranes and vesicles via a concentration-dependent mechanism. Changing solution conditions, e.g., ionic strength and pH, altered the electrostatic interactions between the membrane and mast-MO, resulting in less significant adsorption. This mechanism of action was also validated
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