Evidence map›Paper›PMID 41283146›Full record

ArticleChemical science2026

Amyloidogenic oligomers derived from TDP-43 LCD promote the condensation and phosphorylation of TDP-43.

Bryan Po-Wen Chen, Chi-Chang Lee, Ruei-Yu He, An-Chi Huang, Jie-Rong Huang, Jerry Chun Chung Chan, Joseph Jen-Tse Huang

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bryan Po-Wen ChenInstitute of Chemistry, Academia Sinica Taipei 115 Taiwan jthuang@gate.sinica.edu.tw.ORCID https://orcid.org/0000-0002-8249-0124
Chi-Chang LeeInstitute of Chemistry, Academia Sinica Taipei 115 Taiwan jthuang@gate.sinica.edu.tw.
Ruei-Yu HeInstitute of Chemistry, Academia Sinica Taipei 115 Taiwan jthuang@gate.sinica.edu.tw.
An-Chi HuangInstitute of Chemistry, Academia Sinica Taipei 115 Taiwan jthuang@gate.sinica.edu.tw.
Jie-Rong HuangInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University Taiwan.ORCID https://orcid.org/0000-0003-3674-2228
Jerry Chun Chung ChanDepartment of Chemistry, National Taiwan University Taipei 106 Taiwan chanjcc@ntu.edu.tw.ORCID https://orcid.org/0000-0002-5108-4166
Joseph Jen-Tse HuangInstitute of Chemistry, Academia Sinica Taipei 115 Taiwan jthuang@gate.sinica.edu.tw.ORCID https://orcid.org/0000-0003-4847-7126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aberrant aggregation of TAR DNA-binding protein 43 (TDP-43) is a hallmark of amyotrophic lateral sclerosis (ALS). While TDP-43 aggregation can occur

Identifiers

PMID41283146
PMCPMC12637044

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.