ArticleIndian journal of surgical oncology2025
Study of Immunoexpression of Autophagy Markers- LC3A And LC3B in Cervical Squamous Cell Carcinoma and its Clinicopathological Correlation.
Article in Indian journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer remains a challenge in terms of a cure. The invention of new modalities targeting various pathogenesis related to tumorigenesis has become the latest hot topic of research worldwide. In developing countries, cervical cancer remains one of the most important causes of mortality in women worldwide after breast cancer. Autophagy is a physiological process of intracellular degradation of cytoplasmic components within lysosomes and has been implicated in maintaining homeostasis. Under altered biological/metabolic conditions such as cellular stress, autophagy plays a vital role in cell survival or death. It represents an alternative tumour-suppressing mechanism to overcome the resistance of many cancers to chemotherapy. Microtubule-associated protein-1 light chain-3 (MAP1LC3) gene plays a pivotal role in autophagy, comprising of a soluble LC3A and a non-soluble form LC3B correlating with autophagy after being recruited into autophagosomes, thus considered as a reliable marker in the detection of autophagy. We have done a retrospective archived tissue study on cervical cancer biopsy specimens to study the immunoexpression of autophagy markers LC3A and LC3B and their correlation with clinicopathological parameters. Targeted manipulation of autophagy will provide therapeutic avenues for designing optimal therapeutic strategies in cancer therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.