ArticleIndian journal of surgical oncology2025
Prognostic Impact of HPV-PCR Positivity on Clinicopathological Parameters and Survival Outcomes in Oral Cavity Squamous Cell Carcinoma: A Cross-Sectional Study in Eastern India.
Article in Indian journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The role of human papillomavirus (HPV) in the etiology, staging, and prognosis of oropharyngeal cancer is well established. However, its prognostic impact in oral cavity squamous cell carcinoma (OCSCC) remains less clear. This study aimed to explore the clinicopathological and prognostic implications of HPV positivity in OCSCC. A cross-sectional study was conducted on 140 patients diagnosed with OCSCC at a single center between January 2019 and December 2022. Tumor tissues were collected from biopsy and resected specimens of histologically confirmed OCSCC cases. HPV-PCR was performed using primers for HPV16 and HPV18. Informed consent was obtained from all participants. The study found that 25.7% of OCSCC cases were HPV-positive, exclusively for HPV16. HPV positivity was higher in females compared to males (34.8% vs. 23.9%) and among tobacco users (28.4% vs. 12.5%), though these differences were not statistically significant. HPV-positive tumors were more frequent in earlier stages (pathological stages I and II, 37.5% and 26.3%, respectively) compared to advanced stages. Lymphovascular invasion was more common in the HPV-positive group (36% vs. 16%,
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