ArticleFrontiers in public health2025
Active screening and molecular epidemiological characteristics of fecal colonization by carbapenem-resistant
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Active screening for fecal colonization by carbapenem-resistant Methods: From March 1, 2022 to February 28, 2023, fecal swabs from 435 ICU patients were analyzed using resistant bacteria chromogenic plates. Duplicate strains from the same patient were excluded. Infection prevention and control (IPC) measures were implemented for patients with positive CRE screening results. Bacterial identification, antimicrobial susceptibility testing, multilocus sequence typing (MLST), capsule serotypes, whole-genome sequencing (WGS), and core-genome MLST (cgMLST) were conducted to analyze the molecular epidemiological features and homology of these strains. Results: The prevalence of CRE-FC in ICU wards was 12.6% (55/435). The predominant CRE-FC was Conclusion: CRKP-FC was predominant in CRE-FC. Furthermore, phylogenetic analysis suggested that CRKP-FC had clonal spread in ICU wards, with ST11-KL64 as the main clone. Active CRE-FC screening and IPC interventions can effectively reduced CRE infection rates.
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